Background In the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY),
newborns with asphyxial encephalopathy who received hypothermic therapy had improved …

Background Whether hypothermic therapy improves neurodevelopmental outcomes in
newborn infants with asphyxial encephalopathy is uncertain. Methods We performed a …

Background We previously reported early results of a randomized trial of whole-body
hypothermia for neonatal hypoxic–ischemic encephalopathy showing a significant reduction …

Objectives. To determine the neurodevelopmental outcome of infants treated with head
cooling with systemic hypothermia after hypoxic-ischemic encephalopathy. Study Group …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Background Hypothermia is protective against brain injury after asphyxiation in animal
models. However, the safety and effectiveness of hypothermia in term infants with …

Objectives To systematically review the effectiveness, as determined by survival without
moderate to severe neurodevelopmental disability in infancy and childhood, and the safety …

Therapeutic hypothermia holds promise as a rescue neuroprotective strategy for hypoxic-
ischemic injury, but the incidence of severe neurologic sequelae with hypothermia is …

Objective To determine whether moderate hypothermia after hypoxic-ischaemic
encephalopathy in neonates improves survival and neurological outcome at 18 months of …

BACKGROUND. Whole-body hypothermia reduced the frequency of death or
moderate/severe disabilities in neonates with hypoxic-ischemic encephalopathy in a …