Background: Evolutionarily, immune response is a complex mechanism that protects the
host from internal and external threats. Pattern-recognition receptors (PRRs) recognize …

The mammalian immune system comprises an adaptive and an innate component. The
innate immune system employs a limited number of germ-line-encoded pattern-recognition …

Long-term epigenetic reprogramming of innate immune cells in response to microbes, also
termed" trained immunity," causes prolonged altered cellular functionality to protect from …

We are delighted to present this Research Topic for Frontiers in Immunology, focusing on
“Immunomodulation of Innate Immune Cells”. This collective comprises both primary …

Pattern recognition receptors (PRRs) recognize and respond to evolutionarily conserved
microbespecific molecular patterns and therefore play a critical role in host defense towards …

The innate immune system is the critical first line of defense against infectious and sterile
insults. A cell's ability to sense these insults relies on a series of germline-encoded …

Highlights•Trained immunity reprograms innate immune responses in humans.•Trained
immunity plays a role in the pathophysiology of immune-mediated diseases.•Targeting …

In the initiation of innate immune responses against pathogens, pattern-recognition
receptors (PRRs) have an essential role in recognizing specific components of …

The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

Within immune cells, microbial and self-ligands trigger pattern recognition receptors (PRRs)
to nucleate and activate the signaling organelles of the immune system. Much work in this …