The expression of human thymidine kinase 1 (hTK1) is highly dependent on the growth
states and cell cycle stages in mammalian cells. The amount of hTK1 is significantly …

The fidelity of DNA replication in eukaryotic cells requires a balanced dNTP supply in the S
phase. During the cell cycle progression, the production of dTTP is highly regulated to …

Anaphase promoting complex/cyclosome (APC/C)-mediated proteolysis is essential for
chromosome segregation, mitotic exit, and G1 entry. Here, we show the importance of …

The Anaphase-promoting complex/cyclosome (APC/C) cofactor Cdh1 modulates cell
proliferation by targeting multiple cell-cycle regulators for ubiquitin-dependent degradation …

It has been reported that the polypeptide of thymidine kinase type 1 (TK1) from human and
mouse cells can be modified by phosphorylation. Our laboratory has further shown that the …

TPX2, a microtubule-associated protein, is required downstream of Ran-GTP to induce
spindle assembly. TPX2 activity appears to be tightly regulated during the cell cycle, and we …

CDK4 regulates G 1/S phase transition in the mammalian cell cycle by phosphorylating
retinoblastoma family proteins. However, the mechanism underlying the regulation of CDK4 …

In mammalian cells, salvage pathway phosphorylation of thymidine is catalyzed by two
thymidine kinases: the cell-cycle regulated cytoplasmic TK1 and the constitutively expressed …

Cyclin-dependent kinases (Cdk) promote cell proliferation, are often deregulated in human
cancers, and are targets of ongoing cancer chemotherapy trials. We show here that Cdk …

Cellular supply of dNTPs is essential in the DNA replication and repair processes. Here we
investigated the regulation of thymidine kinase 1 (TK1) in response to DNA damage and …