The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals
is needed to guide vaccine design and immunization strategies. Here we used a large panel …
is needed to guide vaccine design and immunization strategies. Here we used a large panel …
Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression
MJ van Gils, Z Euler, B Schweighardt, T Wrin… - Aids, 2009 - journals.lww.com
Objective: The native envelope gp160 trimer of HIV-1 is thought to shield vulnerable
epitopes that could otherwise elicit effectively neutralizing antibodies. However, little is …
epitopes that could otherwise elicit effectively neutralizing antibodies. However, little is …
Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donors
Defining the specificities of the anti-human immunodeficiency virus type 1 (HIV-1) envelope
antibodies able to mediate broad heterologous neutralization will assist in identifying targets …
antibodies able to mediate broad heterologous neutralization will assist in identifying targets …
Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection
HIV type 1 (HIV-1) can rapidly escape from neutralizing antibody responses. The genetic
basis of this escape in vivo is poorly understood. We compared the pattern of evolution of …
basis of this escape in vivo is poorly understood. We compared the pattern of evolution of …
Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes
Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how
these antibodies develop remain important goals in the quest to rationally develop an HIV-1 …
these antibodies develop remain important goals in the quest to rationally develop an HIV-1 …
Cross-reactive neutralizing humoral immunity does not protect from HIV type 1 disease progression
Z Euler, MJ van Gils, EM Bunnik… - The Journal of …, 2010 - academic.oup.com
Broadly reactive neutralizing antibodies are the focus of human immunodeficiency virus
(HIV) type 1 vaccine design. However, only little is known about their role in acquired …
(HIV) type 1 vaccine design. However, only little is known about their role in acquired …
Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1
B Li, JM Decker, RW Johnson, F Bibollet-Ruche… - Journal of …, 2006 - Am Soc Microbiol
Information about neutralizing antibody responses in subtype C-infected individuals is
limited, even though this viral subtype causes the majority of AIDS cases worldwide. Here …
limited, even though this viral subtype causes the majority of AIDS cases worldwide. Here …
Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection
The study of the evolution and specificities of neutralizing antibodies during the course of
human immunodeficiency virus type 1 (HIV-1) infection may be important in the discovery of …
human immunodeficiency virus type 1 (HIV-1) infection may be important in the discovery of …
Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection
P Hraber, MS Seaman, RT Bailer, JR Mascola… - Aids, 2014 - journals.lww.com
Objective: Studies of neutralizing antibodies in HIV-1 infected individuals provide insights
into the quality of the response that should be possible to elicit with vaccines and ways to …
into the quality of the response that should be possible to elicit with vaccines and ways to …
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
F Klein, C Gaebler, H Mouquet, DN Sather… - Journal of Experimental …, 2012 - rupress.org
Two to three years after infection, a fraction of HIV-1–infected individuals develop serologic
activity that neutralizes most viral isolates. Broadly neutralizing antibodies that recognize the …
activity that neutralizes most viral isolates. Broadly neutralizing antibodies that recognize the …