Background Inflammation is a highly complex biological response evoked by many stimuli. A
persistent challenge in modeling this dynamic process has been the (nonlinear) nature of …

A receptor mediated model of endotoxin-induced human inflammation is proposed. The
activation of the innate immune system in response to the endotoxin stimulus involves the …

Bacterial lipopolysaccharide (LPS) induces an acute inflammatory response across multiple
organs, primarily via Toll-like receptor 4 (TLR4). We sought to define novel aspects of the …

Various stresses elicit an acute, complex inflammatory response, leading to healing but
sometimes also to organ dysfunction and death. We constructed both equation-based …

Inflammation is a complex, non-linear process central to many of the diseases that affect
both developed and emerging nations. A systems-based understanding of inflammation …

Trauma and hemorrhagic shock elicit an acute inflammatory response, predisposing
patients to sepsis, organ dysfunction, and death. Few approved therapies exist for these …

We are now standing at the cusp of systems-based understanding of the processes that
underlie, drive, and control the acute inflammatory response. Based on decades of …

Inflammation is a complex, multiscale biological response to threats–both internal and
external–to the body, which is also required for proper healing of injured tissue. In turn …

Inflammation is a normal, robust physiological process. It can also be viewed as a complex
system that senses and attempts to resolve homeostatic perturbations initiated from within …

The precise inflammatory role of the cytokine interleukin (IL)-6 and its utility as a biomarker
or therapeutic target have been the source of much debate, presumably due to the complex …