Astilbin selectively induces dysfunction of liver-infiltrating cells—novel protection from liver damage

Q Xu, F Wu, J Cao, T Chen, J Jiang, I Saiki… - European Journal of …, 1999 - Elsevier
The present study aimed to examine the effect of astilbin, a flavanoid, on liver injury. When
administered during the effector but not induction phase, astilbin significantly decreased the …

Astilbin prevents concanavalin A-induced liver injury by reducing TNF-α production and T lymphocyte adhesion

J Wang, Y Zhao, Q Xu - Journal of Pharmacy and Pharmacology, 2004 - academic.oup.com
The aim of this study was to evaluate the effect of astilbin on concanavalin A (Con A)-
induced hepatitis, a T cell-dependent model of liver injury. Con A administration resulted in a …

Effect of indole‐3‐carbinol on ethanol‐induced liver injury and acetaldehyde‐stimulated hepatic stellate cells activation using precision‐cut rat liver slices

Y Guo, XQ Wu, C Zhang, ZX Liao, Y Wu… - Clinical and …, 2010 - Wiley Online Library
Indole‐3‐carbinol (I3C), a major indole compound found in high levels in cruciferous
vegetables, shows a broad spectrum of biological activities. However, few studies have …

Tanshinone IIA protects against immune-mediated liver injury through activation of T-cell subsets and regulation of cytokines

XY Qin, T Li, L Yan, QS Liu, Y Tian - Immunopharmacology and …, 2010 - Taylor & Francis
Background and Aim: Tanshione IIA (TSN) is the major active component of Salvia
miltiorrhiza, a traditional Chinese Medicine. TSN protects against antioxidant-induced liver …

The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro

X Bai, P Yang, Q Zhou, B Cai… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose Liver diseases are mostly accompanied by inflammation and
hepatocyte death. Therapeutic approaches targeting both hepatocyte injury and …

Allicin attenuated hepatic ischemia/reperfusion injury in mice by regulating PPARγ-IRAK-M-TLR4 signal pathway

W Li, R Huang, X Gong, Z Zhao, L Zhang, Q Zhou… - Food & Function, 2022 - pubs.rsc.org
Background: Hepatic ischemia/reperfusion (I/R) injury to the liver is a significant cause of
morbidity and mortality following liver surgery, trauma, and hemorrhagic shock. It was …

Fumigaclavine C improves concanavalin A‐induced liver injury in mice mainly via inhibiting TNF‐α production and lymphocyte adhesion to extracellular matrices

Y Zhao, J Liu, J Wang, L Wang, H Yin… - Journal of pharmacy …, 2004 - Wiley Online Library
Fumigaclavine C, an alkaloidal metabolite, was produced by Aspergillus fumigatus (strain
No. CY018). This study examined the effect of this compound on concanavalin A (Con A) …

Antihepatotoxic Effect of Tadehaginoside, Extracted from Tadehagi triquetrum (L.), Against CCl4-Lesioned Rats Through Activating the Nrf2 Signaling Pathway and …

A Tang, X Chen, Q Lu, N Zheng, Y Wei, X Wu - Inflammation, 2014 - Springer
Recently, an increasing number of studies suggest that oxidative stress and inflammation
are associated with hepatocellular injuries. Thus, we aimed to evaluate the potential …

Silibinin protects mice from T cell-dependent liver injury☆

J Schümann, J Prockl, AK Kiemer, AM Vollmar… - Journal of …, 2003 - Elsevier
Background/Aims: Silibinin is the major pharmacologically active compound of the Silybum
marianum fruit extract silymarin. Its well-known hepatoprotective activities are mostly …

Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts

EJ Park, YZ Zhao, YC Kim, DH Sohn - European journal of pharmacology, 2007 - Elsevier
Liver fibrosis and cirrhosis may be reversible, possibly through the selective clearance of
activated hepatic stellate cells/myofibroblasts by apoptosis. Hepatic stellate cells …