The spatial organization of chromatin critically affects genome function. Recent chromosome-
conformation-capture studies have revealed topologically associating domains (TADs) as a …

Recent technological advances in the field of chromosome conformation capture are
facilitating tremendous progress in the ability to map the three-dimensional (3D) …

The mammalian genome is organized into submegabase-sized chromatin domains (CDs)
including topologically associating domains, which have been identified using chromosome …

How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …

Understanding the structure of interphase chromosomes is essential to elucidate regulatory
mechanisms of gene expression. During recent years, high-throughput DNA sequencing …

Three-dimensional genome structure and dynamics play critical roles in regulating DNA
functions. Flexible chromatin structure and movements suggested that the genome is …

Mammalian genomes encode genetic information in their linear sequence, but appropriate
expression of their genes requires chromosomes to fold into complex three-dimensional …

Understanding the mechanisms that underlie chromosome folding within cell nuclei is
essential to determine the relationship between genome structure and function. The recent …

INTRODUCTION Chromatin adopts an intricate three-dimensional (3D) organization in the
nucleus that is critical for many genome processes, from gene regulation to genome …

Traditionally large-scale chromatin structure has been studied by microscopic approaches,
providing direct spatial information but limited sequence context. In contrast, newer 3C …