Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy
insulin-producing beta cells. The aetiology of this complex disease is dependent on the …

Autoimmune diseases are typically studied with a focus on the immune system, and less
attention is paid to responses of target tissues exposed to the immune assault. We presently …

Our ability to successfully intervene in disease processes is dependent on definitive
diagnosis. In the case of autoimmune disease, this is particularly challenging because …

In type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, the pathogenic
destruction of the insulin-producing pancreatic β-cells is under the control of and influenced …

Immune-related adverse events (irAEs) are a notable complication of PD-1 cancer
immunotherapy. A better understanding of how these iatrogenic diseases compare with …

Regulatory T cells (Tregs) control organ-specific autoimmunity in a tissue antigen-specific
manner, yet little is known about their specificity in a natural repertoire. In this study, we used …

Development of autoimmune diabetes in both humans and mice is preceded by a prolonged
period of inflammation of pancreatic islets by autoreactive T-cells. Noninvasive imaging …

Type-1 diabetes in the nonobese diabetic (NOD) mouse starts with an insulitis stage,
wherein a mixed population of leukocytes invades the pancreas, followed by overt diabetes …

Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells
within pancreatic islets. Although insulin is a critical self-antigen in animal models of …