Both oxidative stress and inflammation are enhanced in chronic heart failure. Dysfunction of
cardiac mitochondria is a hallmark of heart failure and a leading cause of oxidative stress …

Advances in cardiovascular research have identified oxidative stress as an important
pathophysiological pathway in the development and progression of heart failure. Oxidative …

Substantial evidence suggests the involvement of oxidative stress in the pathophysiology of
congestive heart failure and its antecedent conditions such as cardiac hypertrophy and …

Over the past several decades, investigations in humans and animal models of heart failure
(HF) have provided substantial evidence that oxidative stress is increased in HF and …

Chronic heart failure (CHF) continues to cause substantial morbidity and mortality despite
major therapeutic advances, such as the use of angiotensin-converting enzyme (ACE) …

Oxidative stress and inflammation are each implicated independently in the development
and progression of heart failure. Their interaction, however, is also evident throughout the …

Inflammation triggered by oxidative stress is the cause of much, perhaps even most, chronic
human disease including human aging. The oxidative stress originates mainly in …

Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative
to antioxidant defense, has been shown to play an important role in the pathophysiology of …

Reactive oxygen species (ROS) are subcellular messengers in gene regulatory and signal
transduction pathways. In pathological situations, ROS accumulate due to excessive …

Heart failure is a growing health burden worldwide characterized by alterations in excitation-
contraction coupling, cardiac energetic deficit and oxidative stress. While current treatments …