The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply
of new antibiotics. It is therefore of great importance to find and create new antibiotics …

Introduction Nucleoside analogues represent a cornerstone of achievement in drug
discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery …

Nucleoside antibiotics constitute an important family of microbial natural products bearing
diverse bioactivities and unusual structural features. Their biosynthetic logics are unique …

Nucleoside antibiotics are a diverse class of natural products with promising biomedical
activities. These compounds contain a saccharide core and a nucleobase. Despite the large …

Antimicrobial resistance in hospital and community settings is growing at an alarming rate
and has been attributed to such organisms as methicillin-resistant staphylococcus aureus …

Modified nucleosides produced by Streptomyces and related actinomycetes are widely used
in agriculture and medicine as antibacterial, antifungal, anticancer and antiviral agents …

Complex nucleoside antibiotics comprise an extensive array of naturalproducts notable for
combining the structural features of nucleosides, higher monosac-charides, disaccharides …

This classification is conventional; someof the antibiotics possess structural features
covering more than two groups in the above classification. For example, liposidomycin B …

Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant
microorganisms. Numerous natural nucleosides and their synthetically modified analogues …

Covering: 2003 to 2009 The quest for new antibiotics, especially those with activity against
Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in …