Background Human studies of genetic risk factors for neural tube defects, severe birth
defects associated with long‐term health consequences in surviving children, have …

The worldwide incidence of neural tube defects (NTDs) ranges from 1.0 to 10.0 per 1,000
births with almost equal frequencies between two major categories: anencephaly and spina …

Structural birth defects are a leading cause of mortality and morbidity in children world‐wide,
affecting as much as 6% of all live births. Among these conditions, neural tube defects …

Neural tube defects (NTDs) are the second most common birth defects (1 in 1000 live births)
in the world. Periconceptional maternal folate supplementation reduces NTD risk by 50 …

Despite compelling epidemiological evidence that folic acid supplements reduce the
frequency of neural tube defects (NTDs) in newborns, common variant association studies …

Purpose Next-generation sequencing has implicated some risk variants for human spina
bifida (SB), but the genome-wide contribution of structural variation to this complex genetic …

Spina bifida refers to a collection of neural tube defects, including myelomeningocele,
meningocele, and myelocele (SBM), as well as lipomyelomeningocele and lipomeningocele …

Spina bifida (SB) is the second most common nonlethal congenital malformation. The
existence of monogenic SB mouse models and human monogenic syndromes with SB …

Abstract Background Neural tube defects (NTDs), which are among the most common
congenital malformations, are influenced by environmental and genetic factors. Low …

Background Folic acid taken in early pregnancy reduces risks for delivering offspring with
several congenital anomalies. The mechanism by which folic acid reduces risk is unknown …