Trapoxin A is a microbial cyclic tetrapeptide that is an essentially irreversible inhibitor of
class I histone deacetylases (HDACs). The inhibitory warhead is the α, β-epoxyketone side …

Trichostatin A (TSA) and trapoxin (TPX) are potent inhibitors of histone deacetylases
(HDACs). TSA is proposed to block the catalytic reaction by chelating a zinc ion in the active …

Histone deacetylases (HDACs) are enzymes that regulate many important biological
pathways. There is a need for the development of isoform-selective HDAC inhibitors for …

Histone deacetylases (HDACs) are essential for the regulation of myriad biological
processes, and their aberrant function is implicated in cancer, neurodegeneration, and other …

Largazole is a macrocyclic depsipeptide originally isolated from the marine cyanobacterium
Symploca sp., which is indigenous to the warm, blue-green waters of Key Largo, Florida …

Histone deacetylases (HDACs) are a family of enzymes found in bacteria, fungi, plants, and
animals that profoundly affect cellular function by catalyzing the removal of acetyl groups …

The cytosolic class IIb histone deacetylase HDAC10 is an emerging target for drug design.
As an inducer of autophagy, its selective inhibition suppresses the autophagic response that …

The discovery of isozyme-selective histone deacetylase (HDAC) inhibitors is critical for
understanding the biological functions of individual HDACs and for validating HDACs as …

Trapoxin, a cyclotetrapeptide isolated from the fungus Helicoma ambiens, profoundly affects
mammalian cell growth and morphology. In this paper, we describe syntheses of …

Phage‐assisted, active site‐directed ligand evolution (PADLE) is a recently developed
technique that uses an amber codon‐encoded noncanonical amino acid (ncAA) as an …