The role of inflammation in cadmium nephrotoxicity: NF-κB comes into view

EHM Hassanein, WR Mohamed, OS Ahmed… - Life Sciences, 2022 - Elsevier
Kidney diseases are major health problem and understanding the underlined mechanisms
that lead to kidney diseases are critical research points with a marked potential impact on …

NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells

H Zhang, L Li, Y Wang, F Dong… - International …, 2016 - spandidos-publications.com
The kidney is one of the primary organs targeted by cadmium (Cd), a widely distributed
environmental pollutant. The glomerular endothelium is the major component of the …

Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-κB pathway in vitro and in vivo

Z Li, H Chi, W Zhu, G Yang, J Song, L Mo, Y Zhang… - Archives of …, 2021 - Springer
Cadmium (Cd) has been reported to induce kidney damage by triggering oxidative stress
and inflammation. The NLR family Pyrin Domain Containing 3 (NLRP3) inflammasome has …

Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative …

AA Obaid, H Almasmoum, RA Almaimani… - Journal of Trace …, 2023 - Elsevier
Abstract Background Cadmium (Cd) is a major environmental pollutant and chronic toxicity
could induce nephropathy by increasing renal oxidative stress and inflammation. Although …

Cadmium-induced kidney injury: Oxidative damage as a unifying mechanism

LJ Yan, DC Allen - Biomolecules, 2021 - mdpi.com
Cadmium is a nonessential metal that has heavily polluted the environment due to human
activities. It can be absorbed into the human body via the gastrointestinal tract, respiratory …

Beneficial effects of Chrysin on Cadmium‐induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO‐1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling …

H Şimşek, N Akaras, C Gür, S Küçükler, FM Kandemir - Gene, 2023 - Elsevier
Cadmium (Cd) is a toxic heavy metal that targets the kidney directly in the body. Chrysin
(CHR) is a natural flavonoid with many properties such as antioxidant, anti-inflammatory and …

[HTML][HTML] Effects of sub-chronic, low-dose cadmium exposure on kidney damage and potential mechanisms

Q Liu, R Zhang, X Wang, X Shen, P Wang… - Annals of …, 2019 - ncbi.nlm.nih.gov
Background The present study was to investigate the potential mechanisms underlying the
sub-chronic low-dose cadmium (Cd) exposure induced renal injury in rats. Methods Totally …

Sinapic acid ameliorate cadmium-induced nephrotoxicity: In vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-κB downregulation

MA Ansari, M Raish, A Ahmad, KM Alkharfy… - Environmental …, 2017 - Elsevier
Cadmium (CD), an environmental and industrial pollutant, generates reactive oxygen
species (ROS) and NOS responsible for oxidative and nitrosative stress that can lead to …

Cadmium toxicity: oxidative stress, inflammation and tissue injury

SC Das, HA Al-Naemi - 2019 - qspace.qu.edu.qa
Cadmium is a known environmental pollutant targeting various organs. Often implicated in
cadmium toxicology is the formation of reactive oxygen species, overwhelming the free …

Cadmium-induced kidney injury in mice is counteracted by a flavonoid-rich extract of bergamot juice, alone or in association with curcumin and resveratrol, via the …

S Cirmi, A Maugeri, A Micali, HR Marini, D Puzzolo… - Biomedicines, 2021 - mdpi.com
Cadmium (Cd) represents a public health risk due to its non-biodegradability and long
biological half-life. The main target of Cd is considered the kidney, where it accumulates. No …