An important pathophysiological consequence of pressure overload‐induced cardiac
hypertrophy is adverse cardiac remodeling, including structural changes in cardiomyocytes …

Cardiac hypertrophy is the underlying cause of heart failure and is characterized by
excessive oxidative stress leading to collagen deposition. Therefore, understanding the …

Recent data show that cardiac hypertrophy contributes substantially to the overall heart
failure burden. Mitochondrial dysfunction is a common feature of cardiac hypertrophy …

Background/Aims: An increase in oxidative stress has been implicated in the
pathophysiology of pressure-overload induced cardiac hypertrophy. Nobiletin (NOB) …

Cardiac fibrosis is a common precursor of ventricular dysfunction and heart failure. We
investigated the role of oxidative stress in myocardial fibrosis and the protective effect of …

Reactive oxygen species (ROS) play a pivotal role in the development of pathological
cardiac hypertrophy. Delphinidin, a natural flavonoid, was reported to exert marked …

Zileuton has been demonstrated to be an anti‐inflammatory agent due to its well‐known
ability to inhibit 5‐lipoxygenase (5‐LOX). However, the effects of zileuton on cardiac …

Aims Resveratrol is a polyphenolic compound that has received much attention for its use in
ameliorating various systemic pathological conditions. The present study was performed to …

Cardiac hypertrophy is accompanied by increased myocardial oxidative stress, and whether
naringenin, a natural antioxidant, is effective in the therapy of cardiac hypertrophy remains …

Oxidative damage and accumulation of extracellular matrix (ECM) components play a
crucial role in the adverse outcome of cardiac hypertrophy. Evidence suggests that nuclear …