Renal ischemia reperfusion injury (IRI) is associated with inflammation, including neutrophil
infiltration that exacerbates the initial ischemic insult. The molecular pathways involved are …

Kidney ischemia–reperfusion injury (IRI) engages both the innate and adaptive immune
responses. Cellular mediators of immunity, such as dendritic cells, neutrophils …

The mechanisms that drive leukocyte recruitment to the kidney are incompletely understood.
Dipeptidase-1 (DPEP1) is a major neutrophil adhesion receptor highly expressed on …

The aim of this study was to investigate the role of TLR2, TLR4 and MyD88 in sepsis-
induced AKI. C57BL/6 TLR2−/−, TLR4−/− and MyD88−/− male mice were subjected to …

Pattern recognition receptors (PRRs) are potent triggers of tissue injury following renal
ischemia/reperfusion injury (IRI). Specific PRRs, such as the toll-like receptor 2 (TLR2) and …

Renal ischemia-reperfusion injury (IRI) is a non-negligible clinical challenge for clinicians in
surgeries such as renal transplantation. Functional loss of renal tubular epithelial cell (TEC) …

Leukocytes, particularly neutrophils, have been implicated in ischemic-reperfusion organ
injury (IRI). However, their role in kidney IRI is controversial. Leukocytes express the …

Leukocytes, cell adhesion molecules and ischemic acute renal failure. Ischemic acute renal
failure (ARF) is a common clinical syndrome, associated with high morbidity and mortality …

Acute renal ischemia elicits an inflammatory response that may exacerbate acute kidney
injury, but the regulation of the initial signals that recruit leukocytes is not well understood …

Damage-associated molecular patterns released from damaged kidney cells initiate
postischemic inflammation, an essential step in the progression of kidney ischemia …