Psychedelics for treatment resistant depression: are they game changers?
M Kalfas, RH Taylor, D Tsapekos… - Expert opinion on …, 2023 - Taylor & Francis
Introduction A new era of treatment for adults with treatment-resistant depression (TRD),
which involves psychedelic substances, is dawning. Emerging evidence indicates that …
which involves psychedelic substances, is dawning. Emerging evidence indicates that …
[HTML][HTML] Quality of acute psychedelic experience predicts therapeutic efficacy of psilocybin for treatment-resistant depression
Introduction: It is a basic principle of the “psychedelic” treatment model that the quality of the
acute experience mediates long-term improvements in mental health. In the present paper …
acute experience mediates long-term improvements in mental health. In the present paper …
[HTML][HTML] Self-administration of Psilocybin in the Setting of Treatment-resistant Depression
A Lyons - Innovations in clinical neuroscience, 2022 - ncbi.nlm.nih.gov
Background Patients diagnosed with major depressive disorder (MDD) who fail to respond
to two or more antidepressants are often considered to have treatment-resistant depression …
to two or more antidepressants are often considered to have treatment-resistant depression …
[HTML][HTML] Psychedelics: threshold of a therapeutic revolution
DJ Heal, SL Smith, SJ Belouin, JE Henningfield - Neuropharmacology, 2023 - Elsevier
ABSTRACT This Special Issue of Neuropharmacology on psychedelics provides a timely
and comprehensive update on progress following the previous Neuropharmacology Special …
and comprehensive update on progress following the previous Neuropharmacology Special …
Role of psychedelics in treatment-resistant depression
Major depressive disorder (MDD) is a serious psychiatric disorder that is characterized by
feelings of sadness and/or loss of interest in pleasurable activities. MDD can affect all age …
feelings of sadness and/or loss of interest in pleasurable activities. MDD can affect all age …
Psilocybin for treatment-resistant depression without psychedelic effects: study protocol for a 4-week, double-blind, proof-of-concept randomised controlled trial
BackgroundRandomised controlled trials (RCTs) of psilocybin have reported large
antidepressant effects in adults with major depressive disorder and treatment-resistant …
antidepressant effects in adults with major depressive disorder and treatment-resistant …
[HTML][HTML] Patient perspectives and experiences with psilocybin treatment for treatment-resistant depression: a qualitative study
JJ Breeksema, A Niemeijer, E Krediet, T Karsten… - Scientific reports, 2024 - nature.com
Psilocybin is the most researched classic psychedelic for Treatment-Resistant Depression
(TRD). While optimizing set and setting are considered essential for efficacy and safety …
(TRD). While optimizing set and setting are considered essential for efficacy and safety …
[HTML][HTML] Psychedelic-assisted psychotherapy for depression: How dire is the need? How could we do it?
M Earleywine, J De Leo - Journal of Psychedelic Studies, 2020 - akjournals.com
Despite the popular support for psychedelics as aids for depression, academics and the
public frequently overestimate the efficacy of available medications and psychotherapies …
public frequently overestimate the efficacy of available medications and psychotherapies …
Psilocybin-assisted psychotherapy for depression: Emerging research on a psychedelic compound with a rich history
There is a serious need for novel therapies that treat individuals with depression, including
major depressive disorder (MDD) and treatment-resistant depression (TRD). An emerging …
major depressive disorder (MDD) and treatment-resistant depression (TRD). An emerging …
[HTML][HTML] Psilocybin for depression: Considerations for clinical trial design
KC O'Donnell, SE Mennenga… - Journal of Psychedelic …, 2019 - akjournals.com
Background and aims Given the enormous global burden of depressive illness, there is an
urgent need to develop novel and more effective treatments for major depressive disorder …
urgent need to develop novel and more effective treatments for major depressive disorder …