Aim: There is considerable interest in approaches that could improve the therapeutic
window of radiotherapy. In this study, hafnium oxide nanoparticles were designed that …

Background Hafnium oxide, NBTXR3 nanoparticles were designed for high dose energy
deposition within cancer cells when exposed to ionizing radiation. The purpose of this study …

Since the discovery of cisplatin about 40 years ago, the design of innovative metal-based
anticancer drugs is a growing area of research. Transition metal coordination complexes …

Nanotechnology, the manipulation of matter on atomic and molecular scales, is a relatively
new branch of science. It has already made a significant impact on clinical medicine …

Enhancement of radiation effects by high-atomic number nanoparticles (NPs) has been
increasingly studied for its potential to improve radiotherapeutic efficacy. The underlying …

Radiotherapy, where ionizing radiation is locally delivered either through an external beam
or by surgically implanting radionuclide-based seeds in the tumor, is one of the gold …

Radiotherapy is currently used in around 50% of cancer treatments and relies on the
deposition of energy directly into tumour tissue. Although it is generally effective, some of the …

Radiation therapy aims to deliver a high therapeutic dose of ionizing radiation to the tumor
volume without exceeding normal tissue tolerance. Preferential tumor uptake of contrast …

Simple Summary Recent advances in nanotechnology gave rise to trials with various types
of metallic nanoparticles (NPs) to enhance the radiosensitization of cancer cells while …

Nanoparticles of high atomic number (Z) materials can act as radiosensitizers to enhance
radiation dose delivered to tumors. An analytical approach is used to calculate dose …