Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV

A Fabarius, A Leitner, A Hochhaus… - Blood, The Journal …, 2011 - ashpublications.org
The prognostic relevance of additional cytogenetic findings at diagnosis of chronic myeloid
leukemia (CML) is unclear. The impact of additional cytogenetic findings at diagnosis on …

Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML

A Fabarius, L Kalmanti, CT Dietz, M Lauseker… - Annals of …, 2015 - Springer
Major route additional cytogenetic aberrations (ACA) at diagnosis of chronic myeloid
leukaemia (CML) indicate an increased risk of progression and shorter survival. Since major …

Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML)

B Hanfstein, MC Müller, R Hehlmann, P Erben… - Leukemia, 2012 - nature.com
In the face of competing first-line treatment options for CML, early prediction of prognosis on
imatinib is desirable to assure favorable survival or otherwise consider the use of a second …

[HTML][HTML] High-risk additional chromosomal abnormalities at low blast counts herald death by CML

R Hehlmann, A Voskanyan, M Lauseker, M Pfirrmann… - Leukemia, 2020 - nature.com
Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether
additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent …

Risk stratification of chromosomal abnormalities in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy

W Wang, JE Cortes, G Tang, JD Khoury… - Blood, The Journal …, 2016 - ashpublications.org
Clonal cytogenetic evolution with additional chromosomal abnormalities (ACAs) in chronic
myelogenous leukemia (CML) is generally associated with decreased response to tyrosine …

Chronic myeloid leukemia: Relevance of cytogenetic and molecular assays

A Bennour, A Saad, H Sennana - Critical reviews in oncology/hematology, 2016 - Elsevier
Chronic myeloid leukemia (CML) is the prototype cytogenetic malignancy. Even before the
development of basic G-and R-banding techniques, CML was found to be associated with a …

Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete …

N Testoni, G Marzocchi, S Luatti… - Blood, The Journal …, 2009 - ashpublications.org
In chronic myeloid leukemia, different methods are available to monitor the response to
therapy: chromosome banding analysis (CBA), interphase fluorescence in situ hybridization …

Clonal chromosomal abnormalities appearing in Philadelphia chromosome–negative metaphases during CML treatment

GC Issa, HM Kantarjian, GN Gonzalez… - Blood, The Journal …, 2017 - ashpublications.org
Clonal chromosomal abnormalities in Philadelphia chromosome-negative (CCA/Ph−)
metaphases emerge as patients with chronic phase chronic myeloid leukemia (CP-CML) are …

Molecular monitoring in chronic myeloid leukemia: response to tyrosine kinase inhibitors and prognostic implications

E Jabbour, JE Cortes, HM Kantarjian - Cancer, 2008 - Wiley Online Library
The majority of patients with chronic‐phase (CP) chronic myeloid leukemia (CML) who are
treated with Bcr‐Abl tyrosine kinase inhibitors such as imatinib and dasatinib achieve …

How I treat newly diagnosed chronic phase CML

J Cortes, H Kantarjian - Blood, The Journal of the American …, 2012 - ashpublications.org
The progress made in the understanding of chronic myeloid leukemia (CML) since the
recognition of a common chromosomal abnormality to the introduction of ever more effective …