Inflammatory caspases, such as caspase-1 and-11, mediate innate immune detection of
pathogens. Caspase-11 induces pyroptosis, a form of programmed cell death, and …

Caspases are either apoptotic or inflammatory. Among inflammatory caspases, caspase-1
and-11 trigger pyroptosis, a form of programmed cell death. Whereas both can be …

The murine caspase-11 non-canonical inflammasome responds to various bacterial
infections. Caspase-11 activation-induced pyroptosis, in response to cytoplasmic …

Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-
binding oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is …

Macrophages mediate crucial innate immune responses via caspase-1-dependent
processing and secretion of interleukin 1β (IL-1β) and IL-18. Although infection with wild …

Abstract Caspase-4/5 in humans and caspase-11 in mice bind hexa-acylated lipid A, the
lipid moeity of lipopolysaccharide (LPS), to induce the activation of non-canonical …

Gram-negative bacteria including Escherichia coli, Citrobacter rodentium, Salmonella
typhimurium, and Shigella flexneri are sensed in an ill-defined manner by an intracellular …

Highlights•Murine caspase-11 senses Gram-negative bacterial infection and triggers
pyroptosis.•Cytoplasmic LPS is the agonist of the caspase-11 pathway.•Caspase-11 and …

Monitoring of the cytosolic compartment by the innate immune system for pathogen-encoded
products or pathogen activities often enables the activation of a subset of caspases. In most …

Dendritic cells (DCs) use pattern recognition receptors to detect microorganisms and
activate protective immunity. These cells and receptors are thought to operate in an all-or …