Aptamer‐Modified Homogeneous Catalysts, Heterogenous Nanoparticle Catalysts, and Photocatalysts: Functional “Nucleoapzymes”,“Aptananozymes”, and “ …

Y Ouyang, MP O'Hagan, B Willner… - Advanced …, 2024 - Wiley Online Library
Conjugation of aptamers to homogeneous catalysts (“nucleoapzymes”), heterogeneous
nanoparticle catalysts (“aptananozymes”), and photocatalysts (“photoaptazymes”) yields …

Nucleoapzymes: hemin/G-quadruplex DNAzyme–aptamer binding site conjugates with superior enzyme-like catalytic functions

E Golub, HB Albada, WC Liao, Y Biniuri… - Journal of the American …, 2016 - ACS Publications
A novel concept to improve the catalytic functions of nucleic acids (DNAzymes) is
introduced. The method involves the conjugation of a DNA recognition sequence (aptamer) …

Cu2+ or Fe3+ Terpyridine/Aptamer Conjugates: Nucleoapzymes Catalyzing the Oxidation of Dopamine to Aminochrome

Y Biniuri, B Albada, M Wolff, E Golub, D Gelman… - ACS …, 2018 - ACS Publications
A concept to tailor catalytic nucleic acid structures is introduced. The method involves the
covalent conjugation of catalytically active metal ion complexes to sequence-specific ligand …

Aptamer-modified Au nanoparticles: Functional nanozyme bioreactors for cascaded catalysis and catalysts for chemodynamic treatment of cancer cells

Y Ouyang, M Fadeev, P Zhang, R Carmieli, J Li… - ACS …, 2022 - ACS Publications
Polyadenine-stabilized Au nanoparticles (pA-AuNPs) reveal dual nanozyme catalytic
activities toward the H2O2-mediated oxidation of dopamine to aminochrome and toward the …

Aptamer-Modified Cu2+-Functionalized C-Dots: Versatile Means to Improve Nanozyme Activities-“Aptananozymes”

Y Ouyang, Y Biniuri, M Fadeev, P Zhang… - Journal of the …, 2021 - ACS Publications
The covalent linkage of aptamer binding sites to nanoparticle nanozymes is introduced as a
versatile method to improve the catalytic activity of nanozymes by concentrating the reaction …

Mimicking Functions of Native Enzymes or Photosynthetic Reaction Centers by Nucleoapzymes and Photonucleoapzymes

M Vázquez-González, Z Zhou, Y Biniuri, B Willner… - Biochemistry, 2020 - ACS Publications
The covalent linkage of catalytic units to aptamer sequence-specific nucleic acids exhibiting
selective binding affinities for substrates leads to functional scaffolds mimicking native …

[HTML][HTML] Rational design of supramolecular hemin/G-quadruplex–dopamine aptamer nucleoapzyme systems with superior catalytic performance

HB Albada, E Golub, I Willner - Chemical Science, 2016 - pubs.rsc.org
The rational design of a set of hemin/G-quadruplex (hGQ)–dopamine binding aptamer
(DBA) conjugates, acting as nucleoapzymes, is described. The nucleoapzyme constructs …

Artificial photosynthesis with electron acceptor/photosensitizer-aptamer conjugates

GF Luo, Y Biniuri, WH Chen, E Neumann… - Nano Letters, 2019 - ACS Publications
Sequence-specific aptamers act as functional scaffolds for the assembly of photosynthetic
model systems. The Ru (II)-tris-bipyridine photosensitizer is conjugated by different binding …

Nucleic acid-functionalized nanozymes and their applications

Y Qin, Y Ouyang, I Willner - Nanoscale, 2023 - pubs.rsc.org
Nanozymes are inorganic, organic and metal–organic framework nanoparticles that reveal
catalytic functions by emulating native enzyme activities. Recently, these nanozymes have …

Aptamer-Functionalized Ce4+-Ion-Modified C-Dots: Peroxidase Mimicking Aptananozymes for the Oxidation of Dopamine and Cytotoxic Effects toward Cancer Cells

Y Ouyang, M Fadeev, P Zhang, R Carmieli… - … applied materials & …, 2022 - ACS Publications
Aptamer-functionalized Ce4+-ion-modified C-dots act as catalytic hybrid systems,
aptananozymes, catalyzing the H2O2 oxidation of dopamine. A series of aptananozymes …