Synthesis and characterization of silica, silver-silica, and zinc oxide-silica nanoparticles for evaluation of blood biochemistry, oxidative stress, and hepatotoxicity in …

A Ali, S Saeed, R Hussain, G Afzal, AB Siddique… - ACS …, 2023 - ACS Publications
Evaluation of nanoparticles (NPs) for biomedical applications has received a lot of attention
for detailed study on pharmacokinetics prior to clinical application. In this study, pure C-SiO2 …

Toxic impacts of amorphous silica nanoparticles on liver and kidney of male adult rats: an in vivo study

RA Azouz, RMS Korany - Biological trace element research, 2021 - Springer
The toxic effects of the amorphous silica nanoparticles have not been thoroughly studied.
Moreover, the majority of the in vivo investigations were performed using an inhalation …

Bioavailability of silica, titanium dioxide, and zinc oxide nanoparticles in rats

MK Kim, JA Lee, MR Jo, SJ Choi - Journal of nanoscience and …, 2016 - ingentaconnect.com
Inorganic nanoparticles have been widely applied to various industrial fields and biological
applications. However, the question as to whether nanoparticles are more efficiently …

Oxidative stress, inflammation, and DNA damage in multiple organs of mice acutely exposed to amorphous silica nanoparticles

A Nemmar, P Yuvaraju, S Beegam, J Yasin… - International journal …, 2016 - Taylor & Francis
The use of amorphous silica (SiO2) in biopharmaceutical and industrial fields can lead to
human exposure by injection, skin penetration, ingestion, or inhalation. However, the in vivo …

In vivo investigation on the chronic hepatotoxicity induced by intraperitoneal administration of 10-nm silicon dioxide nanoparticles

M Almansour, S Alarifi, B Jarrar - International journal of …, 2018 - Taylor & Francis
Background Silicon dioxide (silica) nanoparticles (SDNPs) are widely used in
nanotechnology and medicine, but these nanomaterials may carry a high risk for human …

Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge

JH Kim, CS Kim, RMC Ignacio, DH Kim… - International journal …, 2014 - Taylor & Francis
Silicon dioxide (SiO2) nanoparticles (NPs) have been widely used in the biomedical field,
such as in drug delivery and gene therapy. However, little is known about the biological …

Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity

BM Mohamed, NK Verma, A Prina-Mello… - Journal of …, 2011 - Springer
Abstract Background Nanomaterials such as SiO 2 nanoparticles (SiO 2 NP) are finding
increasing applications in the biomedical and biotechnological fields such as disease …

Oxidative damage and energy metabolism disorder contribute to the hemolytic effect of amorphous silica nanoparticles

L Jiang, Y Yu, Y Li, Y Yu, J Duan, Y Zou, Q Li… - Nanoscale research …, 2016 - Springer
Amorphous silica nanoparticles (SiNPs) have been extensively used in biomedical
applications due to their particular characteristics. The increased environmental and …

Amphipathic silica nanoparticles induce cytotoxicity through oxidative stress mediated and p53 dependent apoptosis pathway in human liver cell line HL-7702 and rat …

D Zuo, Z Duan, Y Jia, T Chu, Q He, J Yuan… - Colloids and Surfaces B …, 2016 - Elsevier
The aim of this study was to evaluate the potential cytotoxicity and the underlying
mechanism of amphipathic silica nanoparticles (SiO 2 NPs) exposure to human normal liver …

Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2

J Ahmad, M Ahamed, MJ Akhtar, SA Alrokayan… - Toxicology and applied …, 2012 - Elsevier
Silica nanoparticles are increasingly utilized in various applications including agriculture
and medicine. In vivo studies have shown that liver is one of the primary target organ of …