The exact role of the fibrinolytic system in the pathogenesis of stroke remains to be
established. Elevated circulating levels of plasminogen activator inhibitor-1, the principle …

High levels of plasminogen activator inhibitor type 1 (PAI-1) have been implicated as a risk
factor for cardiovascular disease, but its precise role remains controversial. The 4G allele of …

Background and Purpose: Decreased fibrinolytic capacity due to increased plasminogen
activator inhibitor-1 (PAI-1) activity and decreased tissue-type plasminogen activator (t-PA) …

The plasminogen activator inhibitor-1 (PAI-1) gene has been found to be associated with the
pathogenesis and progression of vascular diseases including stroke. A 4G/5G, PAI-1 gene …

Mutations in the plasminogen activator inhibitor-1 (PAI-1) gene, along with altered PAI-1 and
tissue-type plasminogen activator (tPA) levels, have been implicated in stroke pathogenesis …

Background—A common 4G allele of a 4G/5G polymorphism in the promoter region of the
plasminogen activator inhibitor-1 (PAI-1) gene is associated with increased transcription of …

Background and Purpose—Impaired fibrinolytic function secondary to elevated plasminogen
activator inhibitor-1 (PAI-1) levels has been implicated in ischemic stroke. PAI-1 levels are …

The 4G/5G polymorphism in the plasminogen activator inhibitor-1 (PAI-1) gene, has been
associated with arterial disease. In this study, we investigated the association of IS in young …

Plasminogen activator inhibitor-1 (PAI-1), a rapid inhibitor of tissue-type plasminogen
activator, has been shown to be an independent risk factor for recurrent myocardial …

To investigate whether the 4G/5G polymorphism of plasminogen activator inhibitor type 1
(PAI-1) and the− 7351 C/T polymorphism of tissue-type plasminogen activator (t-PA) are …