Opioid-free anaesthesia (OFA) is a relatively new and growing field in human medicine.
There are multiple motivations behind this emerging practice with the recognition of several …

This study aimed to compare the analgesic effects of an injectable protocol using multimodal
analgesia with or without opioids in cats undergoing ovariohysterectomy (OVH). Thirty-two …

Opioids have been used for the treatment of pain since 3400 BC by the Mesopotamians and
they remain an important class of analgesic medications. More recently, attention has …

Opioid-free anesthesia is a multimodal anesthesia aimed at avoiding the negative impact of
intraoperative opioid on patient's postoperative outcomes. It is based on the physiology of …

Opioid-free anesthesia (OFA) is emerging as a new stimulating research perspective. The
rationale to propose OFA is based on the aim to avoid the negative impact of intraoperative …

A few years ago, a letter addressed to a medical journal was entitled 'Why doctors prescribe
opioids to known opioid abusers?'questioning the well known abuse and diverted use of …

The feasibility of OFA is evident. However, there are limitations of this approach that warrant
discussion including the potential for adverse drug interactions with multimodal analgesics …

If the use of natural opiates, such as opium, is more than millennial, the history of synthetic
opioids begins after 1950, with the development of the so-called 'modern'anaesthetic …

To the Editor, Opioids have continued to be the mainstay of anesthetic management for
decades. Recently, the concept of opioidfree anesthesia (OFA) has been introduced into …

Opioid-free anaesthesia (OFA) is a term covering a variety of techniques and substances,
generally based on the concept of using opioid-sparing techniques and multimodal …