[HTML][HTML] 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes
The blood-brain barrier (BBB) regulates molecular trafficking, protects against pathogens,
and prevents efficient drug delivery to the brain. Models to date failed to reproduce the …
and prevents efficient drug delivery to the brain. Models to date failed to reproduce the …
Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood–Brain Barrier
JD Wang, ES Khafagy, K Khanafer… - Molecular …, 2016 - ACS Publications
The endothelial cells lining the capillaries supplying the brain with oxygen and nutrients
form a formidable barrier known as the blood–brain barrier (BBB), which exhibits selective …
form a formidable barrier known as the blood–brain barrier (BBB), which exhibits selective …
[HTML][HTML] Engineered human blood–brain barrier microfluidic model for vascular permeability analyses
The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …
therapeutic molecules into the brain. Due to challenges in translating results from animal …
[HTML][HTML] Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells
Abstract Three-dimensional (3D) tissue-engineered models of the blood-brain barrier (BBB)
recapitulate in vivo shear stress, cylindrical geometry, and cell-ECM interactions. Here we …
recapitulate in vivo shear stress, cylindrical geometry, and cell-ECM interactions. Here we …
3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro
The human central nervous system (CNS) vasculature expresses a distinctive barrier
phenotype, the blood–brain barrier (BBB). As the BBB contributes to low efficiency in CNS …
phenotype, the blood–brain barrier (BBB). As the BBB contributes to low efficiency in CNS …
[HTML][HTML] Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation
Background Transwell-based models of the blood–brain barrier (BBB) incorporating
monolayers of human brain microvascular endothelial cells (dhBMECs) derived from …
monolayers of human brain microvascular endothelial cells (dhBMECs) derived from …
Vascularized neural constructs for ex-vivo reconstitution of blood-brain barrier function
Ex-vivo blood-brain barrier (BBB) model is of great value for studying brain function and
drug development, but it is still challenging to engineer macroscale three-dimensional (3D) …
drug development, but it is still challenging to engineer macroscale three-dimensional (3D) …
A pump‐free tricellular blood–brain barrier on‐a‐chip model to understand barrier property and evaluate drug response
Disruption of the blood–brain barrier (BBB) leads to various neurovascular diseases.
Development of therapeutics required to cross the BBB is difficult due to a lack of relevant in …
Development of therapeutics required to cross the BBB is difficult due to a lack of relevant in …
[HTML][HTML] Modeling the blood–brain barrier using stem cell sources
ES Lippmann, A Al-Ahmad, SP Palecek… - Fluids and Barriers of the …, 2013 - Springer
The blood–brain barrier (BBB) is a selective endothelial interface that controls trafficking
between the bloodstream and brain interstitial space. During development, the BBB arises …
between the bloodstream and brain interstitial space. During development, the BBB arises …
[HTML][HTML] Engineering the human blood-brain barrier in vitro
The blood-brain barrier (BBB) is the interface between the vasculature and the brain,
regulating molecular and cellular transport into the brain. Endothelial cells (ECs) that form …
regulating molecular and cellular transport into the brain. Endothelial cells (ECs) that form …