Early Apoptosis of Macrophages Modulated by Injection of Yersinia pestis YopK Promotes Progression of Primary Pneumonic Plague
KN Peters, MO Dhariwala, JM Hughes Hanks… - PLoS …, 2013 - journals.plos.org
Yersinia pestis causes pneumonic plague, a disease characterized by inflammation,
necrosis and rapid bacterial growth which together cause acute lung congestion and …
necrosis and rapid bacterial growth which together cause acute lung congestion and …
Yersinia pestis YopJ Suppresses Tumor Necrosis Factor Alpha Induction and Contributes to Apoptosis of Immune Cells in the Lymph Node but Is Not Required for …
N Lemaître, F Sebbane, D Long… - Infection and …, 2006 - Am Soc Microbiol
The virulence of the pathogenic Yersinia species depends on a plasmid-encoded type III
secretion system that transfers six Yop effector proteins into host cells. One of these proteins …
secretion system that transfers six Yop effector proteins into host cells. One of these proteins …
A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in …
Y Zheng, S Lilo, IE Brodsky, Y Zhang… - PLoS …, 2011 - journals.plos.org
A type III secretion system (T3SS) in pathogenic Yersinia species functions to translocate
Yop effectors, which modulate cytokine production and regulate cell death in macrophages …
Yop effectors, which modulate cytokine production and regulate cell death in macrophages …
YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia
AM Cantwell, SS Bubeck, PH Dube - BMC immunology, 2010 - Springer
Background Yersinia pestis is the causative agent of pneumonic plague; recently, we and
others reported that during the first 24-36 hours after pulmonary infection with Y. pestis pro …
others reported that during the first 24-36 hours after pulmonary infection with Y. pestis pro …
Macrophage Activation Redirects Yersinia-Infected Host Cell Death from Apoptosis to Caspase-1-Dependent Pyroptosis
T Bergsbaken, BT Cookson - PLoS pathogens, 2007 - journals.plos.org
Infection of macrophages by Yersinia species results in YopJ-dependent apoptosis, and
naïve macrophages are highly susceptible to this form of cell death. Previous studies have …
naïve macrophages are highly susceptible to this form of cell death. Previous studies have …
Reduced Apoptosis of Mouse Macrophages Induced by yscW Mutant of Yersinia pestis Results from the Reduced Secretion of YopJ and Relates to Caspase‐3 …
Y Bi, Z Du, H Yang, Z Guo, Y Tan… - … journal of immunology, 2009 - Wiley Online Library
The virulence of the pathogenic Yersinia species depends on a plasmid‐encoded type III
secretion system (T3SS) that injects six Yersinia outer protein (Yop) effector proteins into the …
secretion system (T3SS) that injects six Yersinia outer protein (Yop) effector proteins into the …
Caspase-3 Mediates the Pathogenic Effect of Yersinia pestis YopM in Liver of C57BL/6 Mice and Contributes to YopM's Function in Spleen
Z Ye, AA Gorman, AM Uittenbogaard… - PLoS …, 2014 - journals.plos.org
The virulence protein YopM of the plague bacterium Yersinia pestis has different dominant
effects in liver and spleen. Previous studies focused on spleen, where YopM inhibits …
effects in liver and spleen. Previous studies focused on spleen, where YopM inhibits …
Reduced Secretion of YopJ by Yersinia Limits In Vivo Cell Death but Enhances Bacterial Virulence
IE Brodsky, R Medzhitov - PLoS pathogens, 2008 - journals.plos.org
Numerous microbial pathogens modulate or interfere with cell death pathways in cultured
cells. However, the precise role of host cell death during in vivo infection remains poorly …
cells. However, the precise role of host cell death during in vivo infection remains poorly …
Interaction of Yersinia pestis with Macrophages: Limitations in YopJ-Dependent Apoptosis
A Zauberman, S Cohen, E Mamroud… - Infection and …, 2006 - Am Soc Microbiol
The enteropathogenic Yersinia strains are known to downregulate signaling pathways in
macrophages by effectors of the type III secretion system, in which YopJ/YopP plays a …
macrophages by effectors of the type III secretion system, in which YopJ/YopP plays a …
Yersinia pestis Endowed with Increased Cytotoxicity Is Avirulent in a Bubonic Plague Model and Induces Rapid Protection against Pneumonic Plague
A Zauberman, A Tidhar, Y Levy, E Bar-Haim… - PLoS …, 2009 - journals.plos.org
An important virulence strategy evolved by bacterial pathogens to overcome host defenses
is the modulation of host cell death. Previous observations have indicated that Yersinia …
is the modulation of host cell death. Previous observations have indicated that Yersinia …