[HTML][HTML] AKT and ERK dual inhibitors: the way forward?
Z Cao, Q Liao, M Su, K Huang, J Jin, D Cao - Cancer letters, 2019 - Elsevier
Abstract Phosphatidylinositol 3-kinase (PI3K)/AKT pathway regulates cell growth,
proliferation, survival, mobility and invasion. Mitogen-activated protein kinase …
proliferation, survival, mobility and invasion. Mitogen-activated protein kinase …
Targeting AKT/PKB to improve treatment outcomes for solid tumors
The serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …
Targeting AKT for cancer therapy
M Shariati, F Meric-Bernstam - Expert opinion on investigational …, 2019 - Taylor & Francis
Introduction: Targeted therapies in cancer aim to inhibit specific molecular targets
responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine …
responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine …
Achieving specificity in Akt signaling in cancer
A Toker - Advances in biological regulation, 2012 - Elsevier
Since it's discovery as an effector of PI 3-K (phosphoinositide 3-kinase)(Franke et al., 1995),
the serine/threonine kinase Akt (also known as PKB, protein kinase B) has emerged as a …
the serine/threonine kinase Akt (also known as PKB, protein kinase B) has emerged as a …
[HTML][HTML] Maximising the potential of AKT inhibitors as anti-cancer treatments
JS Brown, U Banerji - Pharmacology & therapeutics, 2017 - Elsevier
Abstract PI3K/AKT signalling is commonly disrupted in human cancers, with AKT being a
central component of the pathway, influencing multiple processes that are directly involved …
central component of the pathway, influencing multiple processes that are directly involved …
Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells
G Cassinelli, V Zuco, L Gatti, C Lanzi… - Current medicinal …, 2013 - ingentaconnect.com
The deregulation of oncogenic signaling pathways which provide survival advantages to
tumor cells is mediated by multiple cellular networks. Among them, the PI3K-Akt-mTOR axis …
tumor cells is mediated by multiple cellular networks. Among them, the PI3K-Akt-mTOR axis …
The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update
CW Lindsley - Current topics in medicinal chemistry, 2010 - ingentaconnect.com
This article describes recent advances in the development and biological evaluation of small
molecule inhibitors for the serine/threonine kinase Akt (PKB) as a reprise of our 2005 review …
molecule inhibitors for the serine/threonine kinase Akt (PKB) as a reprise of our 2005 review …
PI3K/Akt/mTOR pathway inhibitors in cancer: a perspective on clinical progress
P Wu, YZ Hu - Current medicinal chemistry, 2010 - ingentaconnect.com
The phosphoinositide 3-kinase (PI3K)/serine-theronine protein kinase Akt (also known as
protein kinase B (PKB))/mammalian target of rapamycin (mTOR) pathway is a vital …
protein kinase B (PKB))/mammalian target of rapamycin (mTOR) pathway is a vital …
[HTML][HTML] The Akt pathway in oncology therapy and beyond
GM Nitulescu, M Van De Venter… - International …, 2018 - spandidos-publications.com
Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …
death and survival, playing a pivotal role in multiple interconnected cell signaling …
Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery
AKT (also known as PKB) plays a central role in a variety of cellular processes including cell
growth, motility and survival in both normal and tumor cells. The AKT pathway is also …
growth, motility and survival in both normal and tumor cells. The AKT pathway is also …