Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Sirtuins represent a promising new class of conserved histone deacetylases, originally
identified in yeast. The activity of the sirtuin (SirT) family–made up of seven members (SirT1 …

Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic
pathways in prokaryotes and eukaryotes and are involved in many biological processes …

Sirtuins are a family of NAD+-dependent deacetylases (class III histone deacetylases).
Seven mammalian sirtuins, SIRT1-7, are identified, as the functions and locations differ …

Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the
1970s. Because of its function by removing acetylated groups from histones in the presence …

Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …

Sirtuins are NAD+-dependent protein deacetylases that are broadly conserved from bacteria
to humans. Because sirtuins extend the lifespan of yeast, worms and flies, much attention …

Sirtuins are homologs of the yeast silencing information regulator 2 protein, an NAD+-
dependent (histone) deacetylase. In mammals seven different sirtuins, SIRT1–7, have been …

Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined
as a family of nicotinamide adenine dinucleotide-dependent enzymes that deacetylate …

Sirtuin proteins are conserved regulators of aging that have recently emerged as important
modifiers of several diseases which commonly occur later in life such as cancer, diabetes …