Drug monitoring is one strategy of antibiotic stewardship to face antimicrobial resistance.
This strategy could have a determinant role in critically ill patients treated with carbapenems …

Introduction The importance of antibiotic treatment for sepsis in critically ill septic patients is
well established. Consistently achieving the dose of antibiotics required to optimally kill …

Adjusting dosing regimens based on measurements of carbapenem levels may improve
carbapenem exposure in patients. This systematic review aims to describe the effect …

Whether empirical therapy with carbapenems positively affects the outcomes of critically ill
patients with bacterial infections remains unclear. This study aimed to investigate whether …

Background: With increasing knowledge of beta-lactam pharmacodynamics and interpatient
and intrapatient variability in pharmacokinetics, the usefulness of therapeutic drug …

Therapeutic drug monitoring (TDM) is increasingly relevant for an individualized antibiotic
therapy and subsequently a necessary tool to reduce multidrug-resistant pathogens …

Background Beta-lactams (ie, penicillins, cephalosporins, carbapenems, monobactams) are
the most widely used class of antibiotics in critically ill patients. There is substantial …

Therapeutic drug monitoring (TDM) of beta-lactam antibiotics is recommended to address
the variability in exposure observed in critical illness. However, the impact of TDM-guided …

An estimated 70% of critically ill patients receive antibiotics, most frequently beta-lactams.
The pharmacokinetic properties of these substances in this patient population are poorly …

Biomarkers of infection, namely C-reactive protein and procalcitonin (PCT), are potentially
useful in the diagnosis of infection as well as in the assessment of its response to antibiotic …