Natural products as a potential modulator of microglial polarization in neurodegenerative diseases

X Jin, MY Liu, DF Zhang, X Zhong, K Du, P Qian… - Pharmacological …, 2019 - Elsevier
abstract Neurodegenerative diseases (NDs) are characterized by the progressive loss of
structure and function of neurons most common in elderly population, mainly including …

Microglia polarization from M1 to M2 in neurodegenerative diseases

S Guo, H Wang, Y Yin - Frontiers in aging neuroscience, 2022 - frontiersin.org
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …

The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

SF Darwish, AMM Elbadry, AS Elbokhomy… - Frontiers in …, 2023 - frontiersin.org
The pathophysiology of different neurodegenerative illnesses is significantly influenced by
the polarization regulation of microglia and macrophages. Traditional classifications of …

Microglial polarization: novel therapeutic mechanism against Alzheimer's disease

K Yao, H Zu - Inflammopharmacology, 2020 - Springer
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease that results in
progressive dementia, and exhibits high disability and fatality rates. Recent evidence has …

Nutritional and pharmacological strategies to regulate microglial polarization in cognitive aging and Alzheimer's disease

E Peña-Altamira, S Petralla, F Massenzio… - Frontiers in Aging …, 2017 - frontiersin.org
The study of microglia, the immune cells of the brain, has experienced a renaissance after
the discovery of microglia polarization. In fact, the concept that activated microglia can shift …

Pharmacological modulation of functional phenotypes of microglia in neurodegenerative diseases

GJ Song, K Suk - Frontiers in aging neuroscience, 2017 - frontiersin.org
Microglia are the resident innate immune cells of the central nervous system that mediate
brain homeostasis maintenance. Microglia-mediated neuroinflammation is a hallmark …

Role of microglia in neurological disorders and their potentials as a therapeutic target

L Du, Y Zhang, Y Chen, J Zhu, Y Yang… - Molecular neurobiology, 2017 - Springer
Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …

Microglial activation and its implications in the brain diseases

S Thameem Dheen, C Kaur… - Current medicinal …, 2007 - ingentaconnect.com
An inflammatory process in the central nervous system (CNS) is believed to play an
important role in the pathway leading to neuronal cell death in a number of …

Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury

X Yang, S Xu, Y Qian, Q Xiao - Brain, behavior, and immunity, 2017 - Elsevier
Microglia are the primary cells that exert immune function in the central nervous system
(CNS), and accumulating evidence suggests that microglia act as key players in the initiation …

Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases

J Huang, N Huang, S Xu, Y Luo, Y Li, H Jin… - The Journal of nutritional …, 2021 - Elsevier
Abstract Neurodegenerative diseases (NDs), including Alzheimer's disease (AD), and
Parkinson's disease (PD), are characterized by the progressive loss of the structure and …