Epigallocatechin gallate relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages

N Yang, X Li - Biochemical Pharmacology, 2022 - Elsevier
Epigallocatechin gallate (EGCG) is an active catechin in green tea and has multiple
biological functions, such as anti-inflammation, anti-cancer, and immune regulation. This …

[HTML][HTML] Epigallocatechin gallate improves airway inflammation through TGF‑β1 signaling pathway in asthmatic mice

L Shan, X Kang, F Liu, X Cai… - Molecular Medicine …, 2018 - spandidos-publications.com
The present study aimed to investigate the effect of epigallocatechin gallate (EGCG) on
airway inflammation in mice with bronchial asthma, and the regulatory mechanism of …

[HTML][HTML] Epigallocatechin-3-gallate inhibits inflammation and epithelial‑mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma

N Yang, H Zhang, X Cai… - … journal of molecular …, 2018 - spandidos-publications.com
Asthma is a chronic disease associated with hyperresponsiveness, obstruction and
remodeling of the airways. Epithelial-mesenchymal transition (EMT) has an important role in …

[HTML][HTML] An antioxidant ameliorates allergic airway inflammation by inhibiting Hdac 1 via Hif-1α/Vegf axis suppression in mice

R Islam, D Dash, R Singh - Scientific Reports, 2023 - nature.com
Histone deacetylase inhibitors (HDACi) are novel class of drugs as they are involved in post
translational modification of several proteins involved in signaling pathways related to …

Epigallocatechin gallate potentially abrogates fluoride induced lung oxidative stress, inflammation via Nrf2/Keap1 signaling pathway in rats: An in-vivo and in-silico …

T Shanmugam, M Selvaraj, S Poomalai - International …, 2016 - Elsevier
Abstract Background Since this Nrf2-dependent cellular defense response is able to protect
multi-organs, including cancer, neurodegenerative diseases, cardiovascular diseases …

Epigallocatechin gallate ameliorates airway inflammation by regulating Treg/Th17 imbalance in an asthmatic mouse model

N Yang, YX Shang - International immunopharmacology, 2019 - Elsevier
Epigallocatechin gallate (EGCG) is a polyphenol that is found in green tea that has been
shown to ameliorate airway inflammation in an ovalbumin-sensitized asthmatic mouse …

Epigallocatechin-3-gallate protects against the exacerbation of allergic eosinophilic inflammation associated with obesity in mice

DM André, CM Horimoto, MC Calixto… - International …, 2018 - Elsevier
Obesity is linked to worse asthma symptoms. Epigallocatechin-3-gallate (EGCG) reduces
airway inflammation, but no study investigated the effects of EGCG on obesity-associated …

[HTML][HTML] (-)-Epigallocatechin-3-gallate reduces cigarette smoke-induced airway neutrophilic inflammation and mucin hypersecretion in rats

Y Liang, KWK Liu, SC Yeung, X Li, MSM Ip… - Frontiers in …, 2017 - frontiersin.org
Background: Cigarette smoking is the leading cause of chronic obstructive pulmonary
disease.(-)-Epigallocatechin-3-gallate (EGCG), the major catechins in Chinese green tea …

Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese …

H Yu, X Huang, HH Zhu, N Wang, C Xie, YL Zhou… - Phytomedicine, 2023 - Elsevier
Background Obese asthma is one of the important asthma phenotypes that have received
wide attention in recent years. Excessive oxidative stress and different inflammatory …

[HTML][HTML] EGCG promotes PRKCA expression to alleviate LPS-induced acute lung injury and inflammatory response

M Wang, H Zhong, X Zhang, X Huang, J Wang, Z Li… - Scientific reports, 2021 - nature.com
Acute lung injury (ALI), which could be induced by multiple factors such as
lipopolysaccharide (LPS), refer to clinical symptoms of acute respiratory failure, commonly …