Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway
G Ge, J Bai, Q Wang, X Liang, H Tao, H Chen… - Science China Life …, 2022 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease that eventually leads to
disability. Inflammatory cell infiltration, severe joint breaking and systemic bone loss are the …
disability. Inflammatory cell infiltration, severe joint breaking and systemic bone loss are the …
Punicalagin inhibited inflammation and migration of fibroblast-like synoviocytes through NF-κB pathway in the experimental study of rheumatoid arthritis
M Huang, K Wu, S Zeng, W Liu, T Cui… - Journal of …, 2021 - Taylor & Francis
Background The aggressive phenotype of fibroblast-like synoviocytes (FLSs) is essential in
the synovitis and bone destruction in rheumatoid arthritis (RA). Punicalagin is a natural …
the synovitis and bone destruction in rheumatoid arthritis (RA). Punicalagin is a natural …
Punicalagin inhibits inflammation in LPS-induced RAW264. 7 macrophages via the suppression of TLR4-mediated MAPKs and NF-κB activation
X Xu, P Yin, C Wan, X Chong, M Liu, P Cheng, J Chen… - Inflammation, 2014 - Springer
Abstract Punicalagin (2, 3, hexahydroxydiphenoyl-gallagyl-d-glucose and referred to as
PUN) is a bioactive ellagitannin isolated from pomegranate, which is widely used for the …
PUN) is a bioactive ellagitannin isolated from pomegranate, which is widely used for the …
Palmatine protects against MSU-induced gouty arthritis via regulating the NF-κB/NLRP3 and Nrf2 pathways
JJ Cheng, XD Ma, GX Ai, QX Yu, XY Chen… - Drug design …, 2023 - Taylor & Francis
Purpose Gouty arthritis could be triggered by the deposition of monosodium uric acid (MSU)
crystals. Palmatine (PAL), a protoberberine alkaloid, has been proven to possess …
crystals. Palmatine (PAL), a protoberberine alkaloid, has been proven to possess …
A novel drug combination of mangiferin and cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4/NFκB/NLRP3 activation-induced pyroptosis
Growing evidence shows that Baihu-Guizhi decoction (BHGZD), a traditional Chinese
medicine (TCM)-originated disease-modifying anti-rheumatic prescription, may exert a …
medicine (TCM)-originated disease-modifying anti-rheumatic prescription, may exert a …
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages
L Ni, Z Lin, S Hu, Y Shi, Z Jiang, J Zhao, Y Zhou… - Biochemical …, 2022 - Elsevier
Osteoarthritis (OA) is a progressive joint disease characterized by the degradation and
destruction of articular cartilage, which is involved with pathological microenvironmental …
destruction of articular cartilage, which is involved with pathological microenvironmental …
Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in …
J Hu, J Zhou, J Wu, Q Chen, W Du, F Fu, H Yu… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Corni Fructus (CF), the red fruit of Cornus
officinalis Siebold & Zucc, has been used both as food and medicinal herb in traditional …
officinalis Siebold & Zucc, has been used both as food and medicinal herb in traditional …
Piperine inhibits IL-β induced expression of inflammatory mediators in human osteoarthritis chondrocyte
X Ying, X Chen, S Cheng, Y Shen, L Peng… - International …, 2013 - Elsevier
Black pepper (Piper nigrum) is a common remedy in Traditional Chinese Medicine and
possesses diverse biological activities including anti-inflammatory properties. Osteoarthritis …
possesses diverse biological activities including anti-inflammatory properties. Osteoarthritis …
Polyphyllin I ameliorates collagen-induced arthritis by suppressing the inflammation response in macrophages through the NF-κB pathway
Q Wang, X Zhou, Y Zhao, J Xiao, Y Lu, Q Shi… - Frontiers in …, 2018 - frontiersin.org
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by
an increased number of M1-like macrophages in the joints. Polyphyllin I (PPI), one of the …
an increased number of M1-like macrophages in the joints. Polyphyllin I (PPI), one of the …
Curcumin ameliorates monosodium urate‐induced gouty arthritis through Nod‐like receptor 3 inflammasome mediation via inhibiting nuclear factor‐kappa B signaling
X Li, DQ Xu, DY Sun, T Zhang, X He… - Journal of Cellular …, 2019 - Wiley Online Library
Background Monosodium urate (MSU) crystals‐induced inflammation is a key initiator in
gouty arthritis. Curcumin is an active ingredient possessing anti‐inflammatory efficacy. But …
gouty arthritis. Curcumin is an active ingredient possessing anti‐inflammatory efficacy. But …