Loss of RHBDF2 results in an early-onset spontaneous murine colitis
Inflammatory bowel disease (IBD) is a heterogeneous group of inflammation-mediated
pathologies that include Crohn's disease and ulcerative colitis and primarily affects the colon …
pathologies that include Crohn's disease and ulcerative colitis and primarily affects the colon …
Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis
X Li, T Maretzky, JM Perez-Aguilar… - Journal of cell …, 2017 - journals.biologists.com
ABSTRACT A disintegrin and metalloproteinase 17 (ADAM17) controls the release of the
pro-inflammatory cytokine tumor necrosis factor α (TNFα, also known as TNF) and is crucial …
pro-inflammatory cytokine tumor necrosis factor α (TNFα, also known as TNF) and is crucial …
[HTML][HTML] Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
A Chalaris, N Adam, C Sina, P Rosenstiel… - The Journal of …, 2010 - ncbi.nlm.nih.gov
The protease a disintegrin and metalloprotease (ADAM) 17 cleaves tumor necrosis factor
(TNF), L-selectin, and epidermal growth factor receptor (EGF-R) ligands from the plasma …
(TNF), L-selectin, and epidermal growth factor receptor (EGF-R) ligands from the plasma …
High expression of the “A Disintegrin And Metalloprotease” 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases
Background Tumor necrosis factor α (TNF-α) plays a major role in the tissue-damaging
immune response in inflammatory bowel diseases (IBDs). The tissue concentration of TNF-α …
immune response in inflammatory bowel diseases (IBDs). The tissue concentration of TNF-α …
[HTML][HTML] The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of …
JF Chico, M Falk-Paulsen, A Luzius, C Saggau… - Oncotarget, 2018 - ncbi.nlm.nih.gov
The disintegrin metalloprotease ADAM17 has a critical role in intestinal inflammation and
regeneration in mice, as illustrated by the dramatically increased susceptibility of ADAM17 …
regeneration in mice, as illustrated by the dramatically increased susceptibility of ADAM17 …
Epithelial cell-derived a disintegrin and metalloproteinase-17 confers resistance to colonic inflammation through EGFR activation
M Shimoda, K Horiuchi, A Sasaki, T Tsukamoto… - …, 2016 - thelancet.com
Epithelial regeneration is a key process for the recovery from ulcerative colitis (UC). Here we
demonstrate that a disintegrin and metalloproteinase-17 (ADAM17), a main sheddase for …
demonstrate that a disintegrin and metalloproteinase-17 (ADAM17), a main sheddase for …
Critical role of the disintegrin metalloprotease ADAM-like decysin-1 [ADAMDEC1] for intestinal immunity and inflammation
NR O'Shea, TS Chew, J Dunne… - Journal of Crohn's …, 2016 - academic.oup.com
Abstract Background and Aims: ADAM [A Disintegrin And Metalloproteinase] is a family of
peptidase proteins which have diverse roles in tissue homeostasis and immunity. Here, we …
peptidase proteins which have diverse roles in tissue homeostasis and immunity. Here, we …
ADAMTS13 deficiency worsens colitis and exogenous ADAMTS13 administration decreases colitis severity in mice
NL Zitomersky, M Demers, K Martinod, M Gallant… - TH Open, 2017 - thieme-connect.com
Background Inflammatory bowel disease (IBD) affects 1.6 million people in the United
States. IBD is associated with an increased risk of thrombosis, which rises with disease …
States. IBD is associated with an increased risk of thrombosis, which rises with disease …
ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1)
G Weskamp, J Tüshaus, D Li, R Feederle… - Journal of Biological …, 2020 - ASBMB
The metalloprotease ADAM17 (a disintegrin and metalloprotease 17) is a key regulator of
tumor necrosis factor α (TNFα), interleukin 6 receptor (IL-6R), and epidermal growth factor …
tumor necrosis factor α (TNFα), interleukin 6 receptor (IL-6R), and epidermal growth factor …
[HTML][HTML] Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis
PJ Dempsey - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2017 - Elsevier
A disintegrin and metalloproteinases (ADAMs) are a family of mSultidomain, membrane-
anchored proteases that regulate diverse cellular functions, including cell adhesion …
anchored proteases that regulate diverse cellular functions, including cell adhesion …