Human papillomavirus E6 and E7: the cervical cancer hallmarks and targets for therapy

A Pal, R Kundu - Frontiers in microbiology, 2020 - frontiersin.org
Human papillomavirus (HPV)-induced cervical cancer is a major health issue among
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …

Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment

MK Kim, HS Kim, SH Kim, JM Oh, JY Han… - Biochemical …, 2010 - Elsevier
Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical
cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant …

Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins

AM Almeida, JA Queiroz, F Sousa, Â Sousa - Drug discovery today, 2019 - Elsevier
Highlights•Human papillomavirus (HPV) has a primordial role in the development of cervical
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …

[HTML][HTML] Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies

R Bhattacharjee, SS Das, SS Biswal, A Nath… - Critical reviews in …, 2022 - Elsevier
Purpose Cervical cancer (CC), one of the major causes of death of women throughout the
world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region …

Hallmarks of HPV carcinogenesis: The role of E6, E7 and E5 oncoproteins in cellular malignancy

D Estêvão, NR Costa, RMG da Costa… - Biochimica et Biophysica …, 2019 - Elsevier
Human papillomavirus (HPV) is the most common sexually transmitted infectious agent
worldwide, being also responsible for 5% of all human cancers. The integration and …

Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis

Y Nominé, M Masson, S Charbonnier, K Zanier… - Molecular cell, 2006 - cell.com
Oncoprotein E6 is essential for oncogenesis induced by human papillomaviruses (HPVs).
The solution structure of HPV16-E6 C-terminal domain reveals a zinc binding fold. A model …

Functional roles of E6 and E7 oncoproteins in HPV-induced malignancies at diverse anatomical sites

V Tomaić - Cancers, 2016 - mdpi.com
Approximately 200 human papillomaviruses (HPVs) infect human epithelial cells, of which
the alpha and beta types have been the most extensively studied. Alpha HPV types mainly …

Overview of high-risk HPV's 16 and 18 infected cervical cancer: pathogenesis to prevention

S Ramakrishnan, S Partricia, G Mathan - Biomedicine & pharmacotherapy, 2015 - Elsevier
As general, the Human papillomavirus (HPV) causes the most sexually transmitted
diseases. Among well categorized 80 types, the high-risk types HPV's 16 and 18 are highly …

HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor

Q Peng, L Wang, L Zuo, S Gao, X Jiang, Y Han… - Cancer gene …, 2024 - nature.com
Human papillomavirus (HPV) is a class of envelope-free double-stranded DNA virus. HPV
infection has been strongly associated with the development of many malignancies, such as …

Molecular mechanisms of cervical carcinogenesis by high‐risk human papillomaviruses: novel functions of E6 and E7 oncoproteins

T Yugawa, T Kiyono - Reviews in medical virology, 2009 - Wiley Online Library
Over the last two decades, since the initial discovery of human papillomavirus (HPV) type 16
and 18 DNAs in cervical cancers by Dr. Harald zur Hausen (winner of the Nobel Prize in …