A Novel Antifungal Is Active against Candida albicans Biofilms and Inhibits Mutagenic Acetaldehyde Production In Vitro

MT Nieminen, L Novak-Frazer, V Rautemaa… - Plos one, 2014 - journals.plos.org
The ability of C. albicans to form biofilms is a major virulence factor and a challenge for
management. This is evident in biofilm-associated chronic oral-oesophageal candidosis …

Hydroquinones including tetrachlorohydroquinone inhibit Candida albicans biofilm formation by repressing hyphae-related genes

YG Kim, JH Lee, S Park, SK Khadke… - Microbiology …, 2022 - Am Soc Microbiol
Candida albicans is an opportunistic pathogenic fungus responsible for candidiasis. The
pathogen readily forms antifungal agent-resistant biofilms on implanted medical devices or …

Alizarin and Chrysazin Inhibit Biofilm and Hyphal Formation by Candida albicans

RK Manoharan, JH Lee, YG Kim, J Lee - Frontiers in cellular and …, 2017 - frontiersin.org
Candida albicans is one of the most common pathogen causes fungal infections. This
opportunistic pathogen can form biofilms comprised of yeast, hyphae and pseudo hyphal …

Acetaldehyde inhibits the yeast-to-hypha conversion and biofilm formation in Candida albicans

NM Chauhan, JS Raut, SM Karuppayil - Mycoscience, 2011 - Springer
In Candida albicans, alcohol metabolism is implicated in biofilm formation. The alcohol
dehydrogenase gene (ADH1) is involved in the conversion of acetaldehyde to ethanol and …

Screening of Pharmacologically Active Small Molecule Compounds Identifies Antifungal Agents Against Candida Biofilms

T Watamoto, H Egusa, T Sawase, H Yatani - Frontiers in Microbiology, 2015 - frontiersin.org
Candida species have emerged as important and common opportunistic human pathogens,
particularly in immunocompromised individuals. The current antifungal therapies either have …

Susceptibility of Candida albicans biofilms to caspofungin and anidulafungin is not affected by metabolic activity or biomass production

LJ Marcos-Zambrano, P Escribano, E Bouza… - …, 2015 - academic.oup.com
Micafungin is more active against biofilms with high metabolic activity; however, it is
unknown whether this observation applies to caspofungin and anidulafungin and whether it …

A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance

CG Pierce, AK Chaturvedi, AL Lazzell… - npj Biofilms and …, 2015 - nature.com
Methods: To address the pressing need for new antifungals, we have performed a high-
content screen of 20,000 small molecules in a chemical library (NOVACore) to identify …

Cyclooxygenase inhibitors reduce biofilm formation and yeast-hypha conversion of fluconazole resistant Candida albicans

E Abdelmegeed, MI Shaaban - Journal of Microbiology, 2013 - Springer
The incidence of fluconazole-resistant Candida albicans has been increasing worldwide.
Both biofilm and fungal morphogenesis are main virulence factors of C. albicans cells …

Candida virulence and ethanol‐derived acetaldehyde production in oral cancer and non‐cancer subjects

AD Alnuaimi, AN Ramdzan, D Wiesenfeld… - Oral …, 2016 - Wiley Online Library
Objectives To compare biofilm‐forming ability, hydrolytic enzymes and ethanol‐derived
acetaldehyde production of oral Candida isolated from the patients with oral cancer and …

[HTML][HTML] In vitro and in vivo effects of suloctidil on growth and biofilm formation of the opportunistic fungus Candida albicans

B Zeng, J Li, Y Wang, P Chen, X Wang, J Cui, L Liu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
As the most frequent fungal pathogen in humans, Candida albicans can develop serious
drug resistance because its biofilms are resistant to most antifungal agents; this leads to an …