Sodium chloride, as salt, gives rise to hypertension. Nevertheless, individual susceptibility to
the ramifications of sodium chloride is heterogeneous. The conventional nephron-centric …

Hypertension is a major public health concern due to its high prevalence and increased risk
of cardiovascular disease and mortality. Complex traits resulting from both genetic and …

Dysregulation of sodium (Na+) balance is a major cause of hypertensive cardiovascular
disease. The current dogma is that interstitial Na+ readily equilibrates with plasma and that …

Abstract Purpose of Review Dietary sodium is an important trigger for hypertension and
humans show a heterogeneous blood pressure response to salt intake. The precise …

A large and growing body of research suggests that the skin plays an important role in
regulating total body sodium, challenging traditional models of sodium homeostasis that …

Hypertension is a global epidemic affecting over one billion people worldwide. Despite this,
the etiology of most cases of human hypertension remains obscure, and treatment remains …

Cardiovascular diseases (CVDs) are the leading cause of global mortality and include
clinical conditions such as hypertension and heart failure (HF). While several genetic, social …

Salt Handling and Blood Pressure Salt intake is associated with blood pressure, but the
relationship is complex. This review highlights the interplay among renal salt transport, salt …

Hypertension and its consequences, including heart failure, stroke, and kidney disease, are
responsible for substantial morbidity and mortality worldwide. Lifestyle changes, particularly …

Hypertension is a complex trait determined by both genetic and environmental factors and is
a major public health problem due to its high prevalence and concomitant increase in the …