The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling
BY Shorning, MS Dass, MJ Smalley… - International journal of …, 2020 - mdpi.com
Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
Role of PI3K-AKT-mTOR pathway as a pro-survival signaling and resistance-mediating mechanism to therapy of prostate cancer
T Pungsrinont, J Kallenbach, A Baniahmad - International journal of …, 2021 - mdpi.com
Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance
MP Edlind, AC Hsieh - Asian journal of andrology, 2014 - journals.lww.com
Prostate cancer (PCa) is the second most common malignancy among men in the world.
Castration-resistant prostate cancer (CRPC) is the lethal form of the disease, which …
Castration-resistant prostate cancer (CRPC) is the lethal form of the disease, which …
[PDF][PDF] The PI3K/AKT pathway in the pathogenesis of prostate cancer
H Chen, L Zhou, X Wu, R Li, J Wen… - … Biosci (Landmark Ed), 2016 - article.imrpress.com
Despite recent advances in our understanding of the biological behavior of prostate cancer
(PCa), PCa is becoming the most common malignancy in men worldwide. The …
(PCa), PCa is becoming the most common malignancy in men worldwide. The …
Interplay among PI3K/AKT, PTEN/FOXO and AR signaling in prostate cancer
The PI3K signaling pathway is activated in a majority of cancer types. It promotes
tumorigenesis by regulating nutrient metabolism, cell proliferation, survival, migration, and …
tumorigenesis by regulating nutrient metabolism, cell proliferation, survival, migration, and …
PI3K-AKT-mTOR pathway is dominant over androgen receptor signaling in prostate cancer cells
M Kaarbø, ØL Mikkelsen, L Malerød… - Analytical Cellular …, 2010 - content.iospress.com
Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling
are two of the most important pathways implicated in prostate cancer. Previous work has …
are two of the most important pathways implicated in prostate cancer. Previous work has …
AR signaling and the PI3K pathway in prostate cancer
Prostate cancer is a leading cause of cancer-related death in men worldwide. Aberrant
signaling in the androgen pathway is critical in the development and progression of prostate …
signaling in the androgen pathway is critical in the development and progression of prostate …
[HTML][HTML] Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities
P Toren, A Zoubeidi - International journal of oncology, 2014 - spandidos-publications.com
Abstract The PI3K/Akt pathway is an actively pursued therapeutic target in oncology. In
prostate cancer, the activation of this pathway appears to be characteristic of many …
prostate cancer, the activation of this pathway appears to be characteristic of many …
AR and PI3K/AKT in prostate cancer: a tale of two interconnected pathways
E Tortorella, S Giantulli, A Sciarra, I Silvestri - International Journal of …, 2023 - mdpi.com
Prostate cancer (PCa) is the most common cancer in men. The androgen receptor (AR) has
a pivotal role in the pathogenesis and progression of PCa. Many therapies targeting AR …
a pivotal role in the pathogenesis and progression of PCa. Many therapies targeting AR …
Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway
A large number of novel therapeutics is currently undergoing clinical evaluation for the
treatment of prostate cancer, and small molecule signal transduction inhibitors are a …
treatment of prostate cancer, and small molecule signal transduction inhibitors are a …
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