High dietary sugar reshapes sweet taste to promote feeding behavior in Drosophila melanogaster

CE May, A Vaziri, YQ Lin, O Grushko, M Khabiri… - Cell reports, 2019 - cell.com
Recent studies find that sugar tastes less intense to humans with obesity, but whether this
sensory change is a cause or a consequence of obesity is unclear. To tackle this question …

Taste-independent detection of the caloric content of sugar in Drosophila

M Dus, SH Min, AC Keene, GY Lee… - Proceedings of the …, 2011 - National Acad Sciences
Feeding behavior is influenced primarily by two factors: nutritional needs and food
palatability. However, the role of food deprivation and metabolic needs in the selection of …

Integration of taste and calorie sensing in Drosophila

JW Stafford, KM Lynd, AY Jung… - Journal of …, 2012 - Soc Neuroscience
Animals use gustatory information to assess the suitability of potential food sources and
make critical decisions on what to consume. For example, the taste of sugar generally …

Physiological adaptations to sugar intake: new paradigms from Drosophila melanogaster

V Hietakangas, B Lemaitre - Trends in Endocrinology & Metabolism, 2017 - cell.com
Sugars are important energy sources, but high sugar intake poses a metabolic challenge
and leads to diseases. Drosophila melanogaster is a generalist fruit breeder that encounters …

Secondary taste neurons that convey sweet taste and starvation in the Drosophila brain

P Kain, A Dahanukar - Neuron, 2015 - cell.com
The gustatory system provides vital sensory information to determine feeding and appetitive
learning behaviors. Very little is known, however, about higher-order gustatory circuits in the …

Dietary macronutrient imbalances lead to compensatory changes in peripheral taste via independent signaling pathways

A Ganguly, M Dey, C Scott, VK Duong… - Journal of …, 2021 - Soc Neuroscience
Food choice, in animals, has been known to change with internal nutritional state and also
with variable dietary conditions. To better characterize mechanisms of diet-induced plasticity …

Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing

S Fujii, A Yavuz, J Slone, C Jagge, X Song, H Amrein - Current Biology, 2015 - cell.com
Identification of nutritious compounds is dependent on expression of specific taste receptors
in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly …

[HTML][HTML] Presynaptic gain control drives sweet and bitter taste integration in Drosophila

B Chu, V Chui, K Mann, MD Gordon - Current Biology, 2014 - cell.com
The sense of taste is critical in determining the nutritional suitability of foods. Sweet and
bitter are primary taste modalities in mammals, and their behavioral relevance is similar in …

Pharyngeal sense organs drive robust sugar consumption in Drosophila

EE LeDue, YC Chen, AY Jung, A Dahanukar… - Nature …, 2015 - nature.com
The fly pharyngeal sense organs lie at the transition between external and internal nutrient-
sensing mechanisms. Here we investigate the function of pharyngeal sweet gustatory …

Starvation-induced depotentiation of bitter taste in Drosophila

EE LeDue, K Mann, E Koch, B Chu, R Dakin… - Current Biology, 2016 - cell.com
Nutrient deprivation can lead to dramatic changes in feeding behavior, including acceptance
of foods that are normally rejected. In flies, this behavioral shift depends in part on reciprocal …