For all but a few mRNAs, the dynamics of metabolism are unknown. Here, we developed an
experimental and analytical framework for examining these dynamics for mRNAs from …

Based on the above mechanisms of mRNA degradation, an integrated model of mRNA
turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be …

In yeast, the major mRNA degradation pathway is initiated by poly (A) tail shortening that
triggers mRNA decapping. The mRNA is then degraded by 5′-to-3′ exonucleolysis. In …

Degradation of messenger RNAs (mRNAs) plays an essential role in modulation of gene
expression and in quality control of mRNA biogenesis. Nearly all major mRNA decay …

Deadenylation is the major step triggering mammalian mRNA decay. One consequence of
deadenylation is the formation of nontranslatable messenger RNA (mRNA) protein …

The process of eukaryotic gene expression involves a diverse number of steps including
transcription, RNA processing, transport, translation, and mRNA turnover. A critical step in …

Abstract mRNA concentration depends on the balance between transcription and
degradation rates. On both sides of the equilibrium, synthesis and degradation show …

The recognition of the importance of mRNA turnover in regulating eukaryotic gene
expression has mandated the development of reliable, rigorous, and “user‐friendly” …

The steady-state levels of mRNAs depend upon their combined rates of synthesis and
processing, transport from the nucleus to cytoplasm, and decay in the cytoplasm. In …

DIFFERENCES IN degradation rates among messenger RNAs (mRNAs) contribute
significantly to the control of gene expression in eukaryotes. In this review we will focus on …