The healing of deep skin wounds is a complex phenomenon evolving according with a fine
spatiotemporal regulation of different biological events (hemostasis, inflammation …

Several skin equivalent models have been developed to investigate in vitro the re‐
epithelialization process occurring during wound healing. Although these models …

Tissue repair models are essential to explore the pathogenesis of wound healing and scar
formation, identify new drug targets/biomarkers and to test new therapeutics. However, no …

Wound healing and skin scarring models allow the study of the complex processes of scar
formation and wound healing found in the human skin. Models are categorized into in silico …

In vitro models are a cost effective and ethical alternative to study cutaneous wound healing
processes. Moreover, by using human cells, these models reflect the human wound situation …

Numerous difficulties are associated with the conduct of preclinical studies related to skin
and wound repair. Use of small animal models such as rodents is not optimal because of …

Since the early 1990s, our understanding of how epithelial and stromal cells interact in 3D
tissue-engineered constructs has led to tissue-engineered skin and oral mucosa models …

Cutaneous wound-healing disorders are a major health problem that requires the
development of innovative treatments. Whithin this context, the search for reliable human …

Many diseases, as well as side effects of drugs, manifest themselves through skin
symptoms. Skin is a complex tissue that hosts various specialized cell types and performs …

Current therapeutic strategies to reduce scarring in full thickness skin defect offer limited
success due to poor understanding of scar tissue formation and the underlying signaling …