[HTML][HTML] The intrinsically disordered, epigenetic factor RYBP binds to the citrullinating enzyme PADI4 in cancer cells

S Araujo-Abad, M Fuentes-Baile, B Rizzuti… - International Journal of …, 2023 - Elsevier
RYBP (Ring1 and YY 1 binding protein) is a multifunctional, intrinsically disordered protein
(IDP), best described as a transcriptional regulator. It exhibits a ubiquitin-binding …

The nuclear localization sequence of the epigenetic factor RYBP binds to human importin α3

JL Neira, A Jiménez-Alesanco, B Rizzuti… - … et Biophysica Acta (BBA …, 2021 - Elsevier
RYBP (Ring1 and YY1 binding protein, UniProt ID: Q8N488) is an epigenetic factor with a
key role during embryonic development; it does also show an apoptotic function and an …

Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP

S Araujo-Abad, B Rizzuti, M Vidal, O Abian… - Biomolecules, 2024 - mdpi.com
Plakophilin 1 (PKP1), a member of the p120ctn subfamily of the armadillo (ARM)-repeat-
containing proteins, is an important structural component of cell–cell adhesion scaffolds …

The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA

JL Neira, M Román-Trufero, LM Contreras, J Prieto… - Biochemistry, 2009 - ACS Publications
RYBP (Ring1A and YY1 binding protein) is a zinc finger protein with an essential role during
embryonic development, which binds transcriptional factors, Polycomb products, and …

Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells

S Araujo-Abad, B Rizzuti, L Soto-Conde, M Vidal… - International Journal of …, 2024 - Elsevier
Polycomb groups (PcGs) are transcriptional repressors, formed by a complex of several
proteins, involved in multicellular development and cancer epigenetics. One of these …

Multiple roles of Ring 1 and YY 1 binding protein in physiology and disease

S Zhan, T Wang, W Ge, J Li - Journal of cellular and molecular …, 2018 - Wiley Online Library
Ring 1 and YY 1 binding protein (RYBP) was first identified in 1999, and its structure
includes a conserved Npl4 Zinc finger motif at the N‐terminus, a central region that is …

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

VN Uversky, CJ Oldfield… - Journal of Molecular …, 2005 - Wiley Online Library
Regulation, recognition and cell signaling involve the coordinated actions of many players.
To achieve this coordination, each participant must have a valid identification (ID) that is …

Epigenetic and non-epigenetic functions of the RYBP protein in development and disease

CJS da Silva, R Simón, A Busturia - Mechanisms of Ageing and …, 2018 - Elsevier
Over the last decades significant advances have been made in our understanding of the
molecular mechanisms controlling organismal development. Among these mechanisms the …

Phosphorylation of the IDP KID modulates affinity for KIX by increasing the lifetime of the complex

L Dahal, SL Shammas, J Clarke - Biophysical journal, 2017 - cell.com
Intrinsically disordered proteins (IDPs) are known to undergo a range of posttranslational
modifications, but by what mechanism do such modifications affect the binding of an IDP to …

RYBP expression is regulated by KLF4 and Sp1 and is related to hepatocellular carcinoma prognosis

Q Zhao, W Cai, X Zhang, S Tian, J Zhang, H Li… - Journal of Biological …, 2017 - ASBMB
The expression of Ring1-and YY1-binding protein (RYBP) is reduced in several human
cancers, but the molecular mechanism (s) have remained elusive. In this study, we used …