[HTML][HTML] Regulation of phosphosignaling pathways involved in transcription of cell cycle target genes by TRH receptor activation in GH1 cells

Z Drastichova, R Trubacova, J Novotny - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Thyrotropin-releasing hormone (TRH) is known to activate several cellular signaling
pathway, but the activation of the TRH receptor (TRH-R) has not been reported to regulate …

[HTML][HTML] β-Arrestin2 is critically involved in the differential regulation of phosphosignaling pathways by thyrotropin-releasing hormone and taltirelin

Z Drastichova, R Trubacova, J Novotny - Cells, 2022 - mdpi.com
In recent years, thyrotropin-releasing hormone (TRH) and its analogs, including taltirelin
(TAL), have demonstrated a range of effects on the central nervous system that represent …

[HTML][HTML] Biochemical and physiological insights into TRH receptor-mediated signaling

R Trubacova, Z Drastichova, J Novotny - Frontiers in Cell and …, 2022 - frontiersin.org
Thyrotropin-releasing hormone (TRH) is an important endocrine agent that regulates the
function of cells in the anterior pituitary and the central and peripheral nervous systems. By …

[HTML][HTML] Stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics study of a thyroid hormone-regulated secretome in human …

CY Chen, LM Chi, HC Chi, MM Tsai, CY Tsai… - Molecular & Cellular …, 2012 - ASBMB
The thyroid hormone, 3, 3′, 5-triiodo-l-thyronine (T 3), regulates cell growth, development,
differentiation, and metabolism via interactions with thyroid hormone receptors (TRs) …

Biological significance of a thyroid hormone-regulated secretome

CY Chen, MM Tsai, HC Chi, KH Lin - … et Biophysica Acta (BBA)-Proteins and …, 2013 - Elsevier
Abstract The thyroid hormone, 3, 3, 5-triiodo-L-thyronine (T 3), modulates several
physiological processes, including cellular growth, differentiation, metabolism and …

[HTML][HTML] Molecular functions of thyroid hormone signaling in regulation of cancer progression and anti-apoptosis

YC Liu, CT Yeh, KH Lin - International Journal of Molecular Sciences, 2019 - mdpi.com
Several physiological processes, including cellular growth, embryonic development,
differentiation, metabolism and proliferation, are modulated by genomic and nongenomic …

Research resource: identification of novel growth hormone-regulated phosphorylation sites by quantitative phosphoproteomics

BN Ray, HK Kweon, LS Argetsinger… - Molecular …, 2012 - academic.oup.com
GH and GH receptors are expressed throughout life, and GH elicits a diverse range of
responses, including growth and altered metabolism. It is therefore important to understand …

Key signaling molecules in pituitary tumors

CP Tanase, M Neagu, R Albulescu - Expert Review of Molecular …, 2009 - Taylor & Francis
In pituitary tumorigenesis there is cross-talk between fine deregulation of intracellular
pathways and complex microenvironmental factors, processes that can be modulated at …

[HTML][HTML] Cellular action of thyroid hormone

R Sinha, PM Yen - 2015 - europepmc.org
Thyroid hormones (THs) regulate growth, development, metabolism. This chapter aims to
provide a comprehensive overview of the molecular and cellular mechanism (s) for …

[HTML][HTML] Src-dependent phosphorylation at Y406 on the thyroid hormone receptor β confers the tumor suppressor activity

JW Park, L Zhao, P Webb, S Cheng - Oncotarget, 2014 - ncbi.nlm.nih.gov
Association studies suggest that the thyroid hormone receptor β1 (TRβ1) could function as a
tumor suppressor in cancer cells. However, the underlying molecular mechanisms remain to …