BACKGROUND: Matrix metalloproteinase (MMP)-12 has been implicated in the
pathogenesis of both chronic obstructive pulmonary disease (COPD) and asthma. The …

Background: Several matrix metalloproteinases (MMPs) are involved in the pathogenesis of
chronic obstructive pulmonary disease (COPD). In mice, MMP-12 plays a crucial role in the …

BACKGROUND: Animal and human studies have implicated an imbalance of matrix
metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in the …

Asthma and chronic obstructive pulmonary disease (COPD) are different conditions with
contrasting airway inflammation and parenchymal disease patterns. A number of matrix …

Background and objectives Airway remodeling is a main feature of asthma. Different
biological phenotypes of severe asthma have been recently recognized by the ENFUMOSA …

Background Asthma is associated with remodeling of the extracellular matrix (ECM) and
increased airway obstruction, and the mechanisms of this process are unknown. Matrix …

COPD is underdiagnosed and its early assessment is problematic. It has been suggested
that symptomatic smokers with normal FEV1/FVC (Stage 0 COPD, GOLD criteria) can …

Background: The 72 kDa matrix metalloproteinase 2 (MMP-2) and the 92 kDa matrix
metalloproteinase 9 (MMP-9) are type IV collagenases implicated in various aspects of …

Background: The ratio of matrix metalloproteinase-9 (MMP-9) and its inhibitor, tissue
inhibitor of metalloproteinase-1 (TIMP-1) may be a marker of the balance between airway …

Matrix metalloproteinases (MMPs) are elevated in the airways and blood of COPD patients,
contributing to disease pathogenesis and tissue remodelling. However, it is not clear if MMP …