Mass spectrometry-based proteomic technique has become indispensable in current
exploration of complex and dynamic biological processes. Instrument development has …

To a large extent functional diversity in cells is achieved by the expansion of molecular
complexity beyond that of the coding genome. Various processes create multiple distinct but …

Background The purpose of this manuscript is to provide, based on an extensive analysis of
a proteomic data set, suggestions for proper statistical analysis for the discovery of sets of …

Proteogenomics refers to the integrated analysis of the genome and proteome that
leverages mass-spectrometry (MS)-based proteomics data to improve genome annotations …

Protein biomarker development is a multidisciplinary task involving basic, translational and
clinical research. Integration of multidisciplinary efforts in a single pipeline is challenging …

Technologies for genome-wide analyses typically undergo a transition from a discovery
phase to a scoring phase. In the discovery phase, the genomic universe is explored and all …

The spread of “-omics” strategies has strongly changed the way of thinking about the
scientific method. Indeed, managing huge amounts of data imposes the replacement of the …

A proteoform is a defined form of a protein derived from a given gene with a specific amino
acid sequence and localized post‐translational modifications. In top‐down proteomic …

Proteogenomics is an area of research at the interface of proteomics and genomics. In this
approach, customized protein sequence databases generated using genomic and …

Proteomic technology has advanced steadily since the development of'soft-
ionization'techniques for mass-spectrometry-based molecular identification more than two …