Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid

C Dorn, D Petroff, M Stoelzel, MG Kees… - Journal of …, 2021 - academic.oup.com
Objectives To assess plasma and tissue pharmacokinetics of cefazolin and metronidazole in
obese patients undergoing bariatric surgery and non-obese patients undergoing intra …

Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis

MJE Brill, API Houwink, S Schmidt… - Journal of …, 2014 - academic.oup.com
Objectives As morbidly obese patients are prone to surgical site infections, adequate blood
and subcutaneous tissue concentrations of prophylactic antibiotic agents during surgery are …

Plasma and interstitial fluid pharmacokinetics of prophylactic cefazolin in elective bariatric surgery patients

RL Ryan, D Jackson, G Hopkins, V Eley… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Guidelines for surgical prophylactic dosing of cefazolin in bariatric surgery vary in terms of
recommended dose. This study aimed to describe the plasma and interstitial fluid (ISF) …

Antibiotic prophylaxis in bariatric surgery with continuous infusion of cefazolin: determination of concentration in adipose tissue

R Anlicoara, ÁAB Ferraz, K da P. Coelho… - Obesity surgery, 2014 - Springer
Background The aim of this study was to evaluate the concentration of cefazolin in adipose
tissue of patients undergoing bariatric surgery. Methods Eighteen patients undergoing …

Cefazolin dosing for surgical prophylaxis in morbidly obese patients

VP Ho, DP Nicolau, GF Dakin, A Pomp, BS Rich… - Surgical …, 2012 - liebertpub.com
Background: Cefazolin is used commonly to prevent surgical site infection (SSI) after
operations on patients with morbid obesity (MO), but specific dosing guidelines are lacking …

Effectiveness of pre-operative cefazolin in obese patients

NR Unger, BJ Stein - Surgical Infections, 2014 - liebertpub.com
Background: Cefazolin remains the preferred preoperative antibiotic for the majority of
surgical procedures. However, outcome evidence supporting current dosing …

Optimal cefazolin prophylactic dosing for bariatric surgery: no need for higher doses or intraoperative redosing

X Chen, CEM Brathwaite, A Barkan, K Hall, G Chu… - Obesity surgery, 2017 - Springer
Purpose The goal of this pharmacokinetic (PK) study was to evaluate whether a single 2-g
prophylactic dose of cefazolin given (IV) bolus provides effective protective cefazolin levels …

[HTML][HTML] Cefazolin tissue concentrations with a prophylactic dose administered before sleeve gastrectomy in obese patients: a single centre study in 116 patients

R Cinotti, R Dumont, L Ronchi, A Roquilly… - British Journal of …, 2018 - Elsevier
Background In obese patients undergoing sleeve gastrectomy, the blood and fatty-tissue
concentrations of cefazolin required for adequate antibiotic prophylaxis are uncertain …

Determination of total or free cefazolin and metronidazole in human plasma or interstitial fluid by HPLC-UV for pharmacokinetic studies in man

C Dorn, A Kratzer, S Schießer, F Kees, H Wrigge… - … of Chromatography B, 2019 - Elsevier
Cefazolin (CFZ) plus metronidazole (MTZ) is commonly used for perioperative antibiotic
prophylaxis. An HPLC-UV method is described for the simultaneous determination of total or …

Lack of pharmacokinetic basis of weight-based dosing and intra-operative re-dosing with cefazolin surgical prophylaxis in obese patients: implications for antibiotic …

S Blum, CB Cunha, BA Cunha - Surgical Infections, 2019 - liebertpub.com
Traditionally, there have been uniform antibiotic dosing guidelines for prophylaxis for clean–
clean-contaminated surgery in both non-obese and obese adults. All other factors …