Microvascular bioengineering: a focus on pericytes

H Zhao, JC Chappell - Journal of Biological Engineering, 2019 - Springer
Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste
exchange, among other critical functions. Microvascular bioengineering approaches have …

Engineering of a biomimetic pericyte-covered 3D microvascular network

J Kim, M Chung, S Kim, DH Jo, JH Kim, NL Jeon - PloS one, 2015 - journals.plos.org
Pericytes enveloping the endothelium play an important role in the physiology and
pathology of microvessels, especially in vessel maturation and stabilization. However, our …

The impact of pericytes on the stability of microvascular networks in response to nanoparticles

M Dibble, S Di Cio', P Luo, F Balkwill, JE Gautrot - Scientific Reports, 2023 - nature.com
Recapitulating the normal physiology of the microvasculature is pivotal in the development
of more complex in-vitro models and organ-on-chip designs. Pericytes are an important …

Beyond the endothelium: the role of mural cells in vascular biology: in vitro systems to study endothelial/pericyte cell interactions

E Warren, S Gerecht - Vascular Biology, 2023 - vb.bioscientifica.com
The vasculature is crucial for tissue development and survival, and the stability of blood
vessels to perform these functions relies on the interplay between endothelial cells and …

Pericytes in vascular development

LB Payne, M Hoque, C Houk, J Darden… - Current tissue …, 2020 - Springer
Abstract Purpose of Review Pericytes are essential components of capillaries in many
tissues and organs, contributing to vessel stability and integrity, with additional contributions …

A 3D in vitro pericyte-supported microvessel model: visualisation and quantitative characterisation of multistep angiogenesis

E Lee, H Takahashi, J Pauty, M Kobayashi… - Journal of Materials …, 2018 - pubs.rsc.org
Angiogenesis, which refers to the formation of new blood vessels from already existing
vessels, is a promising therapeutic target and a complex multistep process involving many …

[HTML][HTML] Approaches for the isolation and long-term expansion of pericytes from human and animal tissues

VV Alvino, KAK Mohammed, Y Gu… - Frontiers in …, 2023 - frontiersin.org
Pericytes surround capillaries in every organ of the human body. They are also present
around the vasa vasorum, the small blood vessels that supply the walls of larger arteries and …

A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions

MT Rogers, AL Gard, R Gaibler, TJ Mulhern… - Scientific reports, 2021 - nature.com
Microphysiological organ-on-chip models offer the potential to improve the prediction of drug
safety and efficacy through recapitulation of human physiological responses. The …

Implementation of pericytes in vascular regeneration strategies

EM Meijer, CGM van Dijk, R Kramann… - … Engineering Part B …, 2022 - liebertpub.com
For the survival and integration of complex large-sized tissue-engineered (TE) organ
constructs that exceed the maximal nutrients and oxygen diffusion distance required for cell …

The pericyte microenvironment during vascular development

LB Payne, H Zhao, CC James, J Darden… - …, 2019 - Wiley Online Library
Vascular pericytes provide critical contributions to the formation and integrity of the blood
vessel wall within the microcirculation. Pericytes maintain vascular stability and homeostasis …