Protein kinases are enzymes that transfer phosphate to protein, resulting in the modification
of the protein. The human genome encodes approximately 538 kinases. Kinases play a role …

Protein kinases are enzymes that transfer a phosphate group to the threonine, serine, or
tyrosine residues of the target protein, regulating its activity. The activity of these enzymes …

Protein kinases regulate nearly every aspect of cell life, and changes in their expression or
gene mutations cause cancer and other diseases. As many human diseases result from …

Highlights•Kinases constitute a very successful target area comprising now 28 approved
inhibitors.•Despite this success only few first in class kinase inhibitors entered clinical testing …

Protein kinases are essential regulators of cellular functions and responses to extracellular
signals. Through phosphorylation of substrates, protein kinases control cell proliferation and …

Aberrant kinase activity has been implicated in numerous diseases, particularly throughout
oncology. This has led to an intense effort to develop effective kinase inhibitors that has …

Protein kinases modulate the structure and function of proteins by adding phosphate groups
to threonine, tyrosine, and serine residues. The phosphorylation process mediated by the …

Tremendous progress has been made by utilizing kinase inhibitors in oncology, and these
agents continue to pave the way into other areas of medicine. There are, however, many …

Identification of the key roles of protein kinases in cancer has led to extensive efforts to
develop kinase inhibitors for the treatment of a wide range of cancers, and more than 30 …

An expert guide to targeting protein kinases in cancer therapy Research has shown that
protein kinases can instigate the formation and spread of cancer when they transmit faulty …