Liver injury, one of the major side effects of diclofenac (DIC), plagues thousands of patients
who treated with it. Although involvements of metabolic factors, oxidative stress, and …

Diclofenac (DCF) is a widely used nonsteroidal anti-inflammatory drug, but it comes with a
high risk of drug-induced liver injury (DILI). Despite the quinone-imine adduct pathways, the …

The chemokine receptor CXCR3 is functionally pleiotropic, not only recruiting immune cells
to the inflamed liver but also mediating the pathological process of cholestatic liver injury …

Drug‑induced liver injury has become a serious public health problem. Although the
mechanism of acetaminophen (APAP)‑induced liver injury has been studied for decades it …

The nonsteroidal antiinflammatory drug diclofenac causes rare but significant cases of
serious hepatotoxicity, typically with a delayed onset (> 1–3 months). Because there is no …

Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN™) mice exhibit normal hepatic
and extrahepatic biotransformation enzyme activities when compared to wild-type (WT) …

The acyl glucuronide (AG) metabolites of carboxylic acid‐containing drugs are potentially
chemically reactive and are suggested to be implicated in toxicity, including hepatotoxicity …

Diclofenac (DCLF) is a widely used non-steroidal anti-inflammatory drug that is associated
with idiosyncratic, drug-induced liver injury (IDILI) in humans. The mechanisms of DCLF …

METHODS: To prepare an acute liver injury model, CCl 4-induced was intraperitoneally
injected in CAR+/+ and CAR-/-mice. RESULTS: Elevation of serum alanine …

Oxidative stress contributes greatly to initiation and progression of liver injury. Activation of
nuclear-factor erythroid 2-related factor 2 (Nrf2) has been considered as an attractive …