Galleria mellonella as a model system to study virulence potential of mucormycetes and evaluation of antifungal treatment

E Maurer, C Hörtnagl, M Lackner, D Grässle… - Medical …, 2019 - academic.oup.com
Mucorales can cause cutaneous to deep-seated infections, mainly in the
immunocompromised host, resulting in high mortality rates due to late and inefficient …

Hyphae of Rhizopus arrhizus and Lichtheimia corymbifera are more virulent and resistant to antifungal agents than sporangiospores in vitro and in Galleria mellonella

RJR Samdavid Thanapaul, A Roberds, KE Rios… - Journal of Fungi, 2023 - mdpi.com
Mucorales species cause debilitating, life-threatening sinopulmonary diseases in
immunocompromised patients and penetrating wounds in trauma victims. Common …

The mucormycete–host interface

AS Ibrahim, K Voelz - Current opinion in microbiology, 2017 - Elsevier
Highlights•The innate immune system controls mucormycete spores by inhibiting spore
germination.•There is limited evidence for adaptive immunity in combating …

RNAi-based functional genomics identifies new virulence determinants in mucormycosis

TA Trieu, MI Navarro-Mendoza, C Pérez-Arques… - PLoS …, 2017 - journals.plos.org
Mucorales are an emerging group of human pathogens that are responsible for the lethal
disease mucormycosis. Unfortunately, functional studies on the genetic factors behind the …

Animal models to study mucormycosis

ID Jacobsen - Journal of Fungi, 2019 - mdpi.com
Mucormycosis is a rare but often fatal or debilitating infection caused by a diverse group of
fungi. Animal models have been crucial in advancing our knowledge of mechanisms …

Host immune defense upon fungal infections with mucorales: pathogen-immune cell interactions as drivers of inflammatory responses

DE Montaño, K Voigt - Journal of Fungi, 2020 - mdpi.com
During the last few decades, mucormycosis has emerged as one of the most common fungal
infections, following candidiasis and aspergillosis. The fungal order responsible for causing …

Epidemiology, modern diagnostics, and the management of mucorales infections

D Pham, AR Howard-Jones, R Sparks, M Stefani… - Journal of Fungi, 2023 - mdpi.com
Mucormycosis is an uncommon, yet deadly invasive fungal infection caused by the
Mucorales moulds. These pathogens are a WHO-assigned high-priority pathogen group, as …

Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors

MIA Hassan, K Voigt - Medical Mycology, 2019 - academic.oup.com
Fungi of the basal lineage order Mucorales are able to cause infections in animals and
humans. Mucormycosis is a well-known, life-threatening disease especially in patients with …

Generation of A Mucor circinelloides Reporter Strain—A Promising New Tool to Study Antifungal Drug Efficacy and Mucormycosis

U Binder, MI Navarro-Mendoza, V Naschberger… - Genes, 2018 - mdpi.com
Invasive fungal infections caused by Mucorales (mucormycosis) have increased worldwide.
These life-threatening infections affect mainly, but not exclusively, immunocompromised …

Mucormycoses caused by Lichtheimia species

VU Schwartze, ID Jacobsen - Mycoses, 2014 - Wiley Online Library
Mucormycoses are life‐threatening infections with fungi from the order Mucorales
(Mucoromycotina). Although mucormycoses are uncommon compared to other fungal …