Cancers have the ability to develop resistance to traditional therapies, and the increasing
prevalence of these drug resistant cancers necessitates further research and treatment …

Cancer drug resistance leading to therapeutic failure in the treatment of many cancers
encompasses various mechanisms and may be intrinsic relying on the patient's genetic …

Cancer drug resistance continues to be a major impediment in medical oncology. Clinically,
resistance can arise prior to or as a result of cancer therapy. In this review, we discuss …

Systemic therapy often results in the reduction of tumor size but rarely succeeds in
eradicating all cancer cells. Drug efflux, persistence of cancer stem cells (CSCs), epithelial …

Cancer drug resistance is an enormous problem. It is responsible for most relapses in
cancer patients following apparent remission after successful therapy. Understanding …

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …

For many decades classical anti-tumor therapies included chemotherapy, radiation and
surgery; however, in the last two decades, following the identification of the genomic drivers …

Efficacy of chemotherapy in the treatment of distinct malignancies is often hampered by drug
resistance arising in the tumor. Understanding the molecular basis of drug resistance and …

It is becoming increasingly clear that the proliferation of human tumours is driven by a small
proportion of cells, termed tumour stem cells, which have the properties of self-renewal. On …