Background Obesity-associated inflammation is of critical importance in the development of
insulin resistance and non-alcoholic fatty liver disease. Since the cannabinoid receptor CB2 …

Obesity and its metabolic consequences are a major public health concern worldwide.
Obesity is associated with overactivity of the endocannabinoid system, which is involved in …

OBJECTIVE The beneficial effects of the inactivation of endocannabinoid system (ECS) by
administration of antagonists of the cannabinoid receptor (CB) 1 on several pathological …

OBJECTIVE: There is growing evidence for an implication of the CB1 receptor subtype of the
endocannabinoid system in the regulation of eating and fat deposition. To further define the …

Context: Obesity is associated with a low-grade inflammatory state and adipocyte (ADP)
hyperplasia/hypertrophy. Obesity inhibits the “browning” of white adipose tissue …

Abstract Aims Cannabinoid receptor 2 (CB2R) is an important regulator of
immunoinflammatory responses. Interestingly, studies have demonstrated that CB2R was …

Methods: To specifically address the role of CB2 for age-associated obesity, we analyzed
metabolic, cardiovascular, immune and neuronal functions in 1.2–1.8-year-old CB2−/− and …

Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and
changes in plasma lipid profile. Endocannabinoids have been implicated in the …

The cannabinoid receptor 2 (CB2) is well known for its immune modulatory role. However,
recent localisation of CB2 receptors in metabolically active tissue suggests that the CB2 …

Aims/hypothesis The endocannabinoid system has a key role in energy storage and
metabolic disorders. The endocannabinoid receptor 2 (CB2R), which was first detected in …